Soft-tissue sarcoma in adults: An update on the current state of histiotype-specific management in an era of personalized medicine
Soft-tissue sarcoma in adults: An update on the current state of histiotype-specific management in an era of personalized medicine
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DOI：
10.3322/caac.21605
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发表时间：
2020-05-01
影响因子：
254.7
通讯作者：
Cardona, Kenneth
中科院分区：
文献类型：
--
作者：
Gamboa, Adriana C.;Gronchi, Alessandro;Cardona, Kenneth
软组织肉瘤（STS）是一种罕见的肿瘤，占所有成人恶性肿瘤的1%，有超过100种不同的组织学亚型，主要发生在躯干，四肢和腹膜后。这种低发病率进一步复杂化，他们的变量介绍，行为和长期的结果，这强调了集中护理的重要性，在专业中心与多学科团队的方法。在过去的十年中，一直在努力提高基于解剖部位和组织学的STS患者的护理质量，并且多个正在进行的临床试验正在关注针对组织学亚型的定制治疗。本报告总结了指导肢体/躯干和腹膜后STS的组织类型特异性管理的最新证据，包括手术、放疗和化疗。
Soft-tissue sarcomas (STS) are rare tumors that account for 1% of all adult malignancies, with over 100 different histologic subtypes occurring predominately in the trunk, extremity, and retroperitoneum. This low incidence is further complicated by their variable presentation, behavior, and long-term outcomes, which emphasize the importance of centralized care in specialized centers with a multidisciplinary team approach. In the last decade, there has been an effort to improve the quality of care for patients with STS based on anatomic site and histology, and multiple ongoing clinical trials are focusing on tailoring therapy to histologic subtype. This report summarizes the latest evidence guiding the histiotype-specific management of extremity/truncal and retroperitoneal STS with regard to surgery, radiation, and chemotherapy.