Advances in cardiovascular molecular imaging for tracking stem cell therapy.
Advances in cardiovascular molecular imaging for tracking stem cell therapy.
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DOI：
10.1160/th09-08-0530
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发表时间：
2010-07
影响因子：
6.7
通讯作者：
Wu JC
中科院分区：
文献类型：
--
作者：
Ransohoff KJ;Wu JC
与心血管疾病相关的高死亡率部分是由于心脏中缺乏增殖细胞。如果心肌梗死后没有充分的修复，进行性扩张可导致心力衰竭。干细胞疗法为治疗心血管疾病提供了一种有希望的选择，尽管它们使心脏受益的具体机制仍不清楚。在干细胞疗法可以安全地用于人类之前，必须使用创新技术（如多模态分子成像）对其生物学进行研究。本文就放射性核素成像、磁共振成像、生物发光成像和荧光成像的基本原理、标记技术、临床应用及存在的问题进行综述。
The high mortality rate associated with cardiovascular disease is partially due to the lack of proliferative cells in the heart. Without adequate repair following myocardial infarction, progressive dilation can lead to heart failure. Stem cell therapies present one promising option for treating cardiovascular disease, though the specific mechanisms by which they benefit the heart remain unclear. Before stem cell therapies can be used safely in human populations, their biology must be investigated using innovative technologies such as multi-modality molecular imaging. The present review will discuss the basic principles, labeling techniques, clinical applications, and drawbacks associated with four major modalities: radionuclide imaging, magnetic resonance imaging, bioluminescence imaging, and fluorescence imaging.