Lichen planopilaris: report of 30 cases and review of the literature
Lichen planopilaris: report of 30 cases and review of the literature
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DOI：
10.1046/j.1365-4362.2003.01695.x
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发表时间：
2003-05-01
影响因子：
3.6
通讯作者：
Rosina, P
中科院分区：
文献类型：
--
作者：
Chieregato, C;Zini, A;Rosina, P
背景：扁平苔藓（LPP）主要影响头皮，导致鳞屑、萎缩和伴有瘢痕的脱发。我们的研究的目的是获得原始数据LPP和局部治疗的疗效进行评估，比较全身therapy.Methods我们检查了1996年和2001年之间受LPP影响的30例患者，进行临床，实验室，组织病理学和直接免疫荧光检查。其中21名患者（70%）为女性，9名患者（30%）为男性。平均发病年龄为51.5岁。诊断时平均病程为13个月。结果66%的患者炎症反应消失，20%的患者纤维化和瘢痕化程度减轻，13%的患者无反应。结论局部治疗是一种有效的全身治疗方法，尤其是对早期病变的患者。
Background Lichen planopilaris (LPP) affects primarily the scalp, resulting in scaling, atrophy, and alopecia with scarring. The purpose of our study was to obtain original data on LPP and to evaluate the efficacy of topical therapy in comparison with systemic therapies.Methods We examined 30 patients affected by LPP between 1996 and 2001, performing clinical, laboratory, histopathologic and direct immunofluorescence examinations. Twenty-one of the patients (70%) were women and nine (30%) were men. The average age at presentation was 51.5 years. The average duration of the disease was 13 months at the time of the diagnosis. All patients received topical steroids for a total of 12 weeks.Results Resolution of the inflammatory process and blocking of the cicatricial progression were observed in 66% of cases, a mild reduction of fibrosis and cicatrization in 20% of patients, and no response in 13%.Conclusions We concluded that topical therapy may be a valid alternative to systemic therapies, especially in patients with lesions in the early phase.