ERP evidence of semantic processing in children with ASD
ERP evidence of semantic processing in children with ASD
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DOI：
10.1016/j.dcn.2019.100640
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发表时间：
2019-04-01
影响因子：
4.7
通讯作者：
Jeste, Shafali Spurling
中科院分区：
文献类型：
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作者：
DiStefano, Charlotte;Senturk, Damla;Jeste, Shafali Spurling
尽管进行了干预，25%的自闭症谱系障碍(ASD)儿童仍保持最低限度的言语(MV)。脑电图可以揭示ASD患者语言障碍的神经机制，潜在地提高我们预测语言结果和靶向干预的能力。言语(V)和MV ASD儿童以及年龄匹配的典型发育(TD)组参与了语义一致性事件相关电位(ERP)范式，其中图片显示在预期或意想不到的单词之后，N400效应在所有组都明显，TD组潜伏期较短。晚期负成分(LNC)也区分条件，按条件分组，按区域交互作用。后分析显示LNC在TD组的多个区域存在，在MVASD的额中区存在，而在VASD组中不存在。聚类分析确定了ASD参与者中的亚组。两个亚组表现出明显的非典型加工模式，一个是条件的反向但强劲的分化，另一个是最初的反向然后是典型的分化。研究结果表明，自闭症儿童，包括语言最少的儿童，在脑电中显示出语义加工的迹象，但其特点是加工速度迟缓，与心理表征的整合有限。
25% of children with autism spectrum disorder (ASD) remain minimally verbal (MV), despite intervention. Electroencephalography can reveal neural mechanisms underlying language impairment in ASD, potentially improving our ability to predict language outcomes and target interventions. Verbal (V) and MV children with ASD, along with an age-matched typically developing (TD) group participated in a semantic congruence ERP paradigm, during which pictures were displayed followed by the expected or unexpected word.An N400 effect was evident in all groups, with a shorter latency in the TD group. A late negative component (LNC) also differentiated conditions, with a group by condition by region interaction. Post hoc analyses revealed that the LNC was present across multiple regions in the TD group, in the mid-frontal region in MVASD, and not present in the VASD group. Cluster analysis identified subgroups within the ASD participants. Two subgroups showed markedly atypical patterns of processing, one with reversed but robust differentiation of conditions, and the other with initially reversed followed by typical differentiation. Findings indicate that children with ASD, including those with minimal language, showed EEG evidence of semantic processing, but it was characterized by delayed speed of processing and limited integration with mental representations.