Flexible Cationic Nanoparticles with Photosensitizer Cores for Multifunctional Biomedical Applications
Flexible Cationic Nanoparticles with Photosensitizer Cores for Multifunctional Biomedical Applications
复制标题
用于多功能生物医学应用的具有光敏剂核心的柔性阳离子纳米颗粒
DOI：
10.1002/smll.201800201
复制
发表时间：
2018
期刊：
影响因子：
13.3
通讯作者：
Fu-Jian Xu
中科院分区：
文献类型：
--
作者：
Rui Wu;Fu-Jian Xu;Yu Qi;Qiang Zeng;Yuwei Wu;Bingran Yu;Fu-Jian Xu
多模式治疗的一个挑战是开发合适的多功能药物以满足潜在应用的要求。光动力疗法（PDT）被证明是治疗癌症的有效方法。不同的聚阳离子，如乙二胺官能化的聚（甲基丙烯酸缩水甘油酯）（PGED）与丰富的伯胺，仲胺，和羟基基团，表现出良好的基因转染性能。在此，一系列的多功能阳离子纳米粒子（PRP）组成的光敏剂核和PGED壳很容易通过简单的多巴胺涉及的过程中开发的多用途的生物应用。一系列实验表明，PRP纳米颗粒能够有效地介导不同细胞系中的基因递送。PRP纳米粒被进一步证实具有显著的PDT和基因治疗联合用于互补肿瘤治疗的能力。此外，由于其在生物基质中的高分散性，PRP纳米颗粒也可以用于体外和体内成像，具有最小的聚集引起的淬灭。因此，这种具有光敏剂核和聚阳离子壳的柔性纳米平台非常有希望用于具有高功效的多模式肿瘤治疗。
One challenge for multimodal therapy is to develop appropriate multifunctional agents to meet the requirements of potential applications. Photodynamic therapy (PDT) is proven to be an effective way to treat cancers. Diverse polycations, such as ethylenediamine-functionalized poly(glycidyl methacrylate) (PGED) with plentiful primary amines, secondary amines, and hydroxyl groups, demonstrate good gene transfection performances. Herein, a series of multifunctional cationic nanoparticles (PRP) consisting of photosensitizer cores and PGED shells are readily developed through simple dopamine-involving processes for versatile bioapplications. A series of experiments demonstrates that PRP nanoparticles are able to effectively mediate gene delivery in different cell lines. PRP nanoparticles are further validated to possess remarkable capability of combined PDT and gene therapy for complementary tumor treatment. In addition, because of their high dispersities in biological matrix, the PRP nanoparticles can also be used for in vitro and in vivo imaging with minimal aggregation-caused quenching. Therefore, such flexible nanoplatforms with photosensitizer cores and polycationic shells are very promising for multimodal tumor therapy with high efficacy.