A COHORT STUDY OF ALCOHOL-CONSUMPTION AND RISK OF BREAST-CANCER
A COHORT STUDY OF ALCOHOL-CONSUMPTION AND RISK OF BREAST-CANCER
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DOI：
10.1093/oxfordjournals.aje.a116704
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发表时间：
1993-03-01
影响因子：
5
通讯作者：
JAIN, MG
中科院分区：
文献类型：
--
作者：
FRIEDENREICH, CM;HOWE, GR;JAIN, MG
在1982年至1987年期间，56,837名参加加拿大国家乳房筛查研究的妇女中，有519例新发的组织学确诊的乳腺癌病例，研究了饮酒与乳腺癌风险之间的关系。这些妇女在乳腺癌诊断前完成了一份自我管理的食物频率调查问卷，包括饮酒情况。对于整个队列，仅观察到总饮酒量与乳腺癌风险之间的弱关联，与不饮酒者相比，每天饮酒量为30克或更多的人调整后的相对风险为1.22（95%可信区间（Cl） 0.78-1.90）。有证据表明，在入组时处于绝经前的妇女中，随着酒精摄入量的增加，风险单调地增加。与不饮酒者相比，饮酒者调整后的相对危险度在0到
The association between alcohol consumption and breast cancer risk was examined in 519 newly incident, histologically confirmed cases of breast cancer diagnosed between 1982 and 1987 within a cohort of 56,837 women enrolled in the Canadian National Breast Screening Study. These women had completed a self-administered food frequency questionnaire including alcohol consumption at enrollment into the study prior to their breast cancer diagnosis. For the total cohort, only a weak association between total alcohol consumption and breast cancer risk is observed, the adjusted relative risk for those drinking 30 or more g/day being 1.22 (95% confidence interval (Cl) 0.78-1.90) compared with nondrinkers. There is some evidence for a positive association in women who were premenopausal at the time of enrollment for whom there was a monotonic increase in risk with increasing alcohol intake. Compared with nondrinkers, the adjusted relative risk for alcohol consumption of between 0 and