The role of geometric and biomechanical factors in abdominal aortic aneurysm rupture risk assessment.
The role of geometric and biomechanical factors in abdominal aortic aneurysm rupture risk assessment.
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DOI：
10.1007/s10439-013-0786-6
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发表时间：
2013-07
影响因子：
3.8
通讯作者：
Finol, Ender A.
中科院分区：
文献类型：
--
作者：
Raut, Samarth S.;Chandra, Santanu;Shum, Judy;Finol, Ender A.
目前腹主动脉瘤（AAA）疾病的临床管理在很大程度上是基于测量动脉瘤最大直径，以决定何时需要及时干预。数十年的临床证据表明，动脉瘤直径与破裂风险呈正相关，但其他参数也可能在导致或诱发AAA破裂方面发挥作用。几何因素如血管迂曲度、腔内血栓体积和壁表面积与破裂和未破裂AAA的区分有关。通过计算建模技术确定的生物力学因素（如峰值壁应力）与破裂风险呈正相关，其准确性和灵敏度高于单独的最大直径。本综述的目的是检查这些因素，这些因素被发现会影响AAA疾病进展、临床管理和破裂可能性，并强调我们小组在动脉瘤建模和破裂风险评估方面正在进行的研究。
The current clinical management of abdominal aortic aneurysm (AAA) disease is based to a great extent on measuring the aneurysm maximum diameter to decide when timely intervention is required. Decades of clinical evidence show that aneurysm diameter is positively associated with the risk of rupture, but other parameters may also play a role in causing or predisposing the AAA to rupture. Geometric factors such as vessel tortuosity, intraluminal thrombus volume, and wall surface area are implicated in the differentiation of ruptured and unruptured AAAs. Biomechanical factors identified by means of computational modeling techniques, such as peak wall stress, have been positively correlated with rupture risk with a higher accuracy and sensitivity than maximum diameter alone. The objective of this review is to examine these factors, which are found to influence AAA disease progression, clinical management and rupture potential, as well as to highlight on-going research by our group in aneurysm modeling and rupture risk assessment.
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