Occupational solvent exposure, genetic variation in immune genes, and the risk for non-Hodgkin lymphoma.
Occupational solvent exposure, genetic variation in immune genes, and the risk for non-Hodgkin lymphoma.
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DOI：
10.1097/cej.0b013e328354d2c1
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Zhang Y
中科院分区：
文献类型：
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作者：
Deng Q;Zheng T;Lan Q;Lan Y;Holford T;Chen Y;Dai M;Leaderer B;Boyle P;Chanock SJ;Rothman N;Zhang Y
溶剂暴露与非霍奇金淋巴瘤（NHL）的风险不一致。本研究的目的是确定这种关联是否受到免疫基因遗传变异的影响。1996-2000年在康涅狄格州的妇女中进行了一项以人群为基础的病例对照研究，涉及601例NHL事件病例和717例对照。研究了17个免疫基因的30个单核苷酸多态性与暴露于各种溶剂和NHL风险之间的关系。该研究发现，白细胞介素10（IL 10; rs 1800890）的多态性改变了职业暴露于有机溶剂与弥漫性大B细胞淋巴瘤风险之间的关联（相互作用P =0.0058）。在对错误发现率进行调整后，结果仍然具有统计学意义。与从未在职业中接触过任何有机溶剂的女性相比，至少接触过一次有机溶剂的女性如果携带IL 10，患弥漫性大B细胞淋巴瘤的风险显着增加（rs 1800890）TT基因型（比值比=3.31，95%可信区间：1.80-6.08），但如果他们携带AT/AA基因型，（比值比=1.14，95%置信区间：0.72-1.79）。未观察到其他免疫基因单核苷酸多态性和各种溶剂与NHL总体及其主要亚型的显著相互作用。该研究提供了初步证据，支持免疫基因变异在改变职业溶剂暴露与NHL风险之间的关联方面的作用。
Solvent exposure has been inconsistently linked to the risk for non-Hodgkin lymphoma (NHL). The aim of this study was to determine whether the association is modified by genetic variation in immune genes. A population-based case–control study involving 601 incident cases of NHL and 717 controls was carried out in 1996–2000 among women from Connecticut. Thirty single nucleotide polymorphisms in 17 immune genes were examined in relation to the associations between exposure to various solvents and the risk for NHL. The study found that polymorphism in interleukin 10 (IL10; rs1800890) modified the association between occupational exposure to organic solvents and the risk for diffuse large B-cell lymphoma (Pfor interaction=0.0058). The results remained statistically significant after adjustment for false discovery rate. Compared with women who were never occupationally exposed to any organic solvents, women who were exposed to organic solvents at least once had a significantly increased risk for diffuse large B-cell lymphoma if they carried the IL10 (rs1800890) TT genotype (odds ratio=3.31, 95% confidence interval: 1.80–6.08), but not if they carried the AT/AA genotype (odds ratio=1.14, 95% confidence interval: 0.72–1.79). No significant interactions were observed for other immune gene single nucleotide polymorphisms and various solvents in relation to NHL overall and its major subtypes. The study provided preliminary evidence supporting a role of immune gene variations in modifying the association between occupational solvent exposure and the risk for NHL.