Central demyelinating disorders and hepatitis B vaccination:: a risk-benefit approach for pre-adolescent vaccination in France
Central demyelinating disorders and hepatitis B vaccination:: a risk-benefit approach for pre-adolescent vaccination in France
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DOI：
10.1016/s0264-410x(02)00053-1
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发表时间：
2002-05-15
期刊：
影响因子：
5.5
通讯作者：
Drucker, J
中科院分区：
文献类型：
--
作者：
Lévy-Bruhl, D;Desenclos, JC;Drucker, J
该研究的目的是为免疫政策决策者提供青春期前疫苗接种的风险效益分析。有关乙型肝炎疫苗接种与中枢性脱髓鞘 (FECD) 疾病首次发作之间关联的存在及其强度的各种情况。风险评估为接种疫苗和 FECD 发病之间不同时间间隔内 FECD 的可归因风险，以及每年接种疫苗队列中预防的急性暴发性乙型肝炎和肝硬化数量的益处。即使在最坏的情况下，疫苗接种所预防的并发症数量在数量上也超过了潜在风险。即使天平的双方具有不同的医学和社会学性质，这一结果也有利于加强法国的青春期前疫苗接种策略。 (C) 2002 Elsevier Science Ltd. 保留所有权利。
The objective of the study was to provide immunization policy decision makers with a risk-benefit analysis for pre-adolescents vaccination. for various scenarios regarding the existence and the strength of an association between hepatitis B vaccination and the occurrence of first episode of central demyelinating (FECD) disease. The risks were assessed as the attributable risks of FECD for various time intervals between vaccination and onset of FECD and the benefits as the number of acute fulminant hepatitis B and cirrhosis prevented in a vaccinated annual cohort. Even in the worst-case considered, the number of complications prevented by the vaccination outweighs quantitatively the potential risks. Even if both sides of the balance are of different medical and sociological nature, this result is in favor of reinforcing the pre-adolescent vaccination strategy in France. (C) 2002 Elsevier Science Ltd. All rights reserved.