A reticular pattern of intrinsic connections in primate area V2 (area 18).
A reticular pattern of intrinsic connections in primate area V2 (area 18).
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灵长类动物 V2 区（18 区）内在连接的网状图案。
DOI：
10.1002/cne.902350405
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Rockland,KS
中科院分区：
文献类型：
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作者：
Rockland,KS
在松鼠和猕猴的V2区(18区)，通过大量注射氚氨基酸、辣根过氧化物酶(HRP)和荧光乳胶微珠，证明了一个周期性的内在联系系统。这些联系起源于集中在第3层和第5层的锥体神经元。终末存在于所有皮质层，大部分与标记神经元同延，但更局限于第4层。这种多层分布与V1(第17区)周期性固有联系的主要颗粒上定位形成对比，可能暗示V2中周期性固有联系与枕叶皮质以及皮质终末(分别集中在第3层和第5层，以及较低的第3和4层)之间存在密切的相互作用。与V1一样，V2中这些连接的切向构型为网状或网格状，距离HRP、~3H氨基酸或乳胶珠的注射部位2.5-3.0 mm即可检测到。标记区域的横截面宽度在松鼠猴中从250到800μm不等，在猕猴中从400到1,000μm不等，这取决于测量到的格子的哪一部分。将周期性固有联系与细胞色素氧化酶(CO)组织化学标记的条带进行比较，两者之间没有明显的联系。这一结果与报道的V2的CO反应区和某些外在连接之间有序的切向排列形成了对比，即枕皮质终末(Livingstone和Hubel，‘82)和投射到V4区的神经元簇(DeYoe和Van Essen，’84)。然而，其他外在连接，如从V2到V1的反向连接，似乎没有周期性的分布。因此，尽管一些不连续的皮质连接以精确的马赛克方式相互联系，但内在连接和一些外部连接可能观察到不同的组织模式。
A system of periodic intrinsic connections is demonstrated in area V2 (area 18) of squirrel and macaque monkeys by large injections of tritiated amino acids, horseradish peroxidase (HRP), and fluorescent latex beads. These connections originate from pyramidal neurons concentrated in layers 3 and 5. Terminations occur in all cortical layers, largely coextensive with labeled neurons but more restricted in layer 4. This multilaminar distribution contrasts with the mainly supragranular localization of periodic intrinsic connections in V1 (area 17), and may imply a close interaction, in V2, of periodic intrinsic connections with pulvinocortical, as well as with corticocortical terminations (concentrated, respectively, in layers 3 and 5, and in lower 3 and 4). As in V1, the tangential configuration of these connections in V2 is reticular or latticelike, and is detectable for 2.5–3.0 mm from an injection site of HRP,3H amino acids, or latex beads. Cross‐sectional widths of labeled regions vary from 250 to 800 μm in squirrel monkey and from 400 to 1,000 μm in macaque, depending on which portion of the lattice is measured. When periodic intrinsic connections are compared with stripes labeled histochemically by cytochrome oxidase (CO), no clear relationship is obvious between the two systems. This result contrasts with the orderly tangential alignment reported between CO‐reactive zones in V2 and certain extrinsic connections; namely, pulvinocortical terminations (Livingstone and Hubel, '82) and clusters of neurons projecting to area V4 (DeYoe and Van Essen, '84). Other extrinsic connections, however, such as backgoing connections from V2 to V1, do not seem to have a periodic distribution. Thus, although some discontinuous cortical connections relate to each other in a precise mosaic fashion, intrinsic and some extrinsic connections may observe different modes of organization.