The specificity of neuropsychological impairment in predicting antidepressant non-response in the very old depressed.
The specificity of neuropsychological impairment in predicting antidepressant non-response in the very old depressed.
复制标题
神经心理损伤在预测高龄抑郁症患者抗抑郁药无反应方面的特异性。
DOI：
10.1002/gps.1889
复制
发表时间：
2008
影响因子：
4
通讯作者：
Roose,StevenP
中科院分区：
文献类型：
--
作者：
Sneed,JoelR;Keilp,JohnG;Brickman,AdamM;Roose,StevenP
在早期的报道中，反应抑制预测了晚年抑郁症中抗抑郁药的无反应（Sneed et al.，2007年）。本研究的目的是为了确定这种效果是否是特定的反应抑制或是否在其他认知领域的损害也预示nonresponse.Methodolder抑郁症患者（n= 84）参加了为期8周的西酞普兰试验被归类为受损或非受损相对于样本的精神状态，心理速度，反应时间，空间判断，和记忆，和对比方面的抗抑郁response. ResultsWho受损的患者相对于数字符号性能的样本没有迅速响应西酞普兰作为那些谁是未受损。然而，在为期8周的试验结束时，两组都达到了相同的反应水平。在其他领域的损害没有影响到抗抑郁response.ConclusionsNon-response是不属于任何的神经心理学测试的损害，这表明抗抑郁药的非反应是特定的反应抑制受损。版权所有© 2007约翰威利父子有限公司.
ObjectiveIn an earlier report, response inhibition predict antidepressant non-response in late-life depression (Sneed et al., 2007). The purpose of this study was to ascertain whether this effect is specific to response inhibition or whether impairment in other cognitive domains also predicts non-response.MethodOlder depressed patients (n= 84) enrolled in an 8-week trial of citalopram were classified as impaired or non-impaired relative to the sample on mental status, psychomotor speed, reaction time, spatial judgment, and memory, and contrasted with regard to antidepressant response.ResultsPatients who were impaired relative to the sample on digit symbol performance did not respond as quickly to citalopram as those who were unimpaired. By the end of the 8-week trial, however, both groups reached the same level of response. Impairment in other domains had no impact on antidepressant response.ConclusionsNon-response was not attributable to impairment on any of the neuropsychological tests suggesting that antidepressant non-response is specific to impaired response inhibition. Copyright© 2007 John Wiley & Sons, Ltd.