Enantioselective Iridium-Catalyzed Ring Opening of Low-Activity Azabenzonorbornadienes with Amines
Enantioselective Iridium-Catalyzed Ring Opening of Low-Activity Azabenzonorbornadienes with Amines
复制标题
铱催化胺对映选择性低活性氮苯降冰片二烯开环
DOI：
10.1021/acs.organomet.8b00239
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发表时间：
2018-05
期刊：
影响因子：
2.8
通讯作者：
Liao Jianhua
中科院分区：
文献类型：
--
作者：
Luo Renshi;Cheng Gengjinsheng;Wei Yifei;Deng Rinuan;Huang Miao;Liao Jianhua
由[Ir（coe）2Cl]2和氮磷配体原位生成的铱催化剂（2.5mol%）在低活性的氮杂苯并降冰片二烯与各种脂肪胺和芳香胺的不对称开环反应中是有效的，以高产率（高达98%）和优异的对映选择性（高达97%ee）提供相应的手性邻位1，2-二胺支架。通过进行克级反应证明了转化的合成效用。
An iridium catalyst (2.5 mol %) generated in situ from [Ir(coe)2Cl]2 and a nitrogen phosphorus ligand was efficient in the asymmetric ring-opening reactions of low-activity azabenzonorbornadiene with various aliphatic and aromatic amines, providing the corresponding chiral vicinal 1,2-diamine scaffolds in high yields (up to 98%) and excellent enantioselectivities (up to 97% ee). The synthetic utility of the transformation was demonstrated by performing a gram-scale reaction.