Health-related quality of life in patients with narcolepsy
Health-related quality of life in patients with narcolepsy
复制标题
DOI：
10.1016/j.sleep.2006.10.010
复制
发表时间：
2007-11-01
期刊：
影响因子：
4.8
通讯作者：
Mayer, Geert
中科院分区：
文献类型：
--
作者：
Dodel, Richard;Peter, Helga;Mayer, Geert
背景资料：评价发作性睡病患者的健康相关生活质量（HRQoL）。方法：受试者包括75例发作性睡病患者，诊断在Hephata Klinik，德国，谁符合国际睡眠障碍分类（ICSD）标准发作性睡病。采用标准化电话访谈，询问疾病及其对患者的负担。使用36项简明医学结局研究（SF-36）以及Euroqol（EQ-5D）记录HRQoL。使用双变量和多变量analysis.Results：发作性睡病患者的SF-36的所有8个领域的分数相比，一般德国人口的频率和因素的影响降低HRQoL进行了评估。特别是，在“身体作用”、“活力”和“一般健康感知”方面的得分很差。48%的患者报告了至少一项EQ-5D项目的问题;最常见的是“日常活动”（63.8%）、“疼痛/不适”（61.7%）和“焦虑/抑郁”（41.1%）维度的问题。只有6.8%的人记录到难以维持“自我护理”。VAS评分平均为60.7%。有趣的是，发作性睡病的体征和症状，除了不可抗拒的睡眠发作（p < 0.03），对HRQoL的影响很小。多变量分析证实了就业状况，生活与合作伙伴，过多的日间嗜睡（EDS）和professional advancement.Conclusions：HRQoL的强烈影响是相当大的减少患者，发作性睡病影响到不同程度的不同尺寸。临床体征和症状以外的因素也与HRQoL较差相关。应采取措施将这些因素纳入医疗指南，以提高嗜睡症患者的生活质量。(C)2007年由Elsevier B. V.出版。
Background: To evaluate the health-related quality of life (HRQoL) in patients suffering from narcolepsy.Methods: Subjects included 75 narcoleptic patients diagnosed at the Hephata Klinik, Germany, who met the International Classification of Sleep Disorders (ICSD) criteria for narcolepsy. A standardized telephone interview was used to inquire about the disease and its burdens to the patients. HRQoL was recorded using the 36-item short-form Medical Outcomes Study (SF-36) as well as the Euroqol (EQ-5D). Frequency and factors of influence on decreased HRQoL were evaluated by using bivariate and multivariate analyses.Results: Patients with narcolepsy had considerably lower scores on all eight domains of the SF-36 compared to the general German population. In particular, scores were poor for the dimensions "physical role", "vitality", and "general health perception". Fortyeight percent of the patients reported problems in at least one of the EQ-5D items; most frequent were problems in the dimension "usual activity" (63.8%), "pain/discomfort" (61.7%) and "anxiety/depression" (41.1%). Difficulty maintaining "self-care" was documented only by 6.8%. Themean VAS score was 60.7%. Interestingly, signs and symptoms of narcolepsy, except for irresistible sleep episodes (p < 0.03), had only a minor impact on HRQoL. Multivariate analyses confirmed a strong influence of employment status, living with a partner, excessive daytime sleepiness (EDS) and professional advancement.Conclusions: HRQoL is considerably reduced in patients, with narcolepsy affecting the different dimensions to various degrees. Factors other than clinical signs and symptoms are associated also with poor HRQoL. Measures should be taken to integrate those factors into healthcare guidelines in order to improve the quality of life in patients with narcolepsy. (C) 2007 Published by Elsevier B.V.