Antagonistic interactions between Wingless and decapentaplegic responsible for dorsal-ventral pattern in the Drosophila leg
Antagonistic interactions between Wingless and decapentaplegic responsible for dorsal-ventral pattern in the Drosophila leg
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DOI：
10.1126/science.273.5280.1373
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发表时间：
1996-09-06
期刊：
影响因子：
56.9
通讯作者：
Cohen, SM
中科院分区：
文献类型：
--
作者：
Brook, WJ;Cohen, SM
果蝇的肢原基再分裂为前室和后室，引发了细胞间的相互作用，形成了腿和翅膀的图案。一个类似的隔室为基础的机制是用来图案的背腹轴的翅膀。这里提出的证据是基于细胞相互作用的机制，而不是在车厢的形成，区分背腹侧的腿。无翅和十肢麻痹信号系统的相互抑制产生了一个稳定的调节回路，每个基因通过该回路在空间受限的结构域中维持其自身的表达。在发育过程中，其他生物也可以使用独立于隔室的模式化机制。
Subdivision of the limb primordia of Drosophila into anterior and posterior compartments triggers cell interactions that pattern the legs and wings. A comparable compartment-based mechanism is used to pattern the dorsal-ventral axis of the wing. Evidence is presented here for a mechanism based on cell interaction, rather than on compartment formation, that distinguishes dorsal from ventral in the leg. Mutual repression by Wingless and Decapentaplegic signaling systems generates a stable regulatory circuit by which each gene maintains its own expression in a spatially restricted domain. Compartment-independent patterning mechanisms may be used by other organisms during development.