Prefrontal direct current stimulation modulates resting EEG and event-related potentials in healthy subjects: A standardized low resolution tomography (sLORETA) study
Prefrontal direct current stimulation modulates resting EEG and event-related potentials in healthy subjects: A standardized low resolution tomography (sLORETA) study
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DOI：
10.1016/j.neuroimage.2010.12.004
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发表时间：
2011-03-15
期刊：
影响因子：
5.7
通讯作者：
Mulert, C.
中科院分区：
文献类型：
--
作者：
Keeser, D.;Padberg, F.;Mulert, C.
据报道，将阳极置于左背外侧前额叶皮层（DLPFC）的前额叶经颅直流电刺激（tDCS）可增强健康受试者的工作记忆，并改善重度抑郁症患者的情绪。然而，其公认的抗抑郁认知和行为作用还没有得到很好的理解。在这里，我们评估了神经元电活动变化的分布后，阳极tDCS的左DLPFC和阴极tDCS的右眶上区使用频谱功率分析和标准化低分辨率断层扫描（sLORETA）。在一项双盲、安慰剂对照交叉试验中，10名健康受试者在不同日期接受了真实的和假tDCS。在左侧DLPFC上以2 mA强度施加阳极tDCS 20 min，而阴极定位在对侧眶上区域上。在tDCS后，在闭眼休息状态下记录EEG，然后进行工作记忆（n-back）任务。统计非参数映射显示在真实的tDCS条件下左额叶三角洲活动减少。具体而言，一个显着减少的平均电流密度（sLORETA）的δ带中检测到左膝下PFC，前扣带回和左内侧额回。而且，作用在前5 min最强（p
Prefrontal transcranial direct current stimulation (tDCS) with the anode placed on the left dorsolateral prefrontal cortex (DLPFC) has been reported to enhance working memory in healthy subjects and to improve mood in major depression. However, its putative antidepressant cognitive and behavior action is not well understood. Here, we evaluated the distribution of neuronal electrical activity changes after anodal tDCS of the left DLPFC and cathodal tDCS of the right supraorbital region using spectral power analysis and standardized low resolution tomography (sLORETA). Ten healthy subjects underwent real and sham tDCS on separate days in a double-blind, placebo-controlled cross-over trial. Anodal tDCS was applied for 20 min at 2 mA intensity over the left DLPFC, while the cathode was positioned over the contralateral supraorbital region. After tDCS, EEG was recorded during an eyes-closed resting state followed by a working memory (n-back) task. Statistical non-parametric mapping showed reduced left frontal delta activity in the real tDCS condition. Specifically, a significant reduction of mean current densities (sLORETA) for the delta band was detected in the left subgenual PFC, the anterior cingulate and in the left medial frontal gyrus. Moreover, the effect was strongest for the first 5 min (p