Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.
Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.
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DOI：
10.1016/j.cellsig.2008.11.015
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发表时间：
2009-04
影响因子：
4.8
通讯作者：
Toker A
中科院分区：
文献类型：
--
作者：
Chin YR;Toker A
丝氨酸/苏氨酸蛋白激酶Akt是所有细胞和组织中磷脂酰肌醇3-K(Pi3-K)途径的主要信号转导通路，在维持细胞生长、增殖、存活和代谢等细胞过程中起着关键作用。PI3-K/Akt通路在人类癌症中的频繁异常激活使其成为一个有吸引力的治疗靶点。大量研究已经对Akt信号在癌细胞以及周围肿瘤微环境中的具体功能有了全面的了解，这为针对Pi3-K和Akt的治疗药物的开发提供了信息和支持。然而，最近的研究已经证明了三种哺乳动物Akt亚型的不同功能，特别是在调节细胞运动和乳腺癌转移方面。在这里，我们讨论Akt信号在侵袭性迁移和肿瘤转移中的作用机制，并重点介绍我们对Akt通路在肿瘤相关间质中的作用的理解的最新进展。
The serine/threonine protein kinase Akt is a major signal transducer of the phosphoinositide 3-kinase (PI 3-K) pathway in all cells and tissues and plays a pivotal role in the maintenance of cellular processes including cell growth, proliferation, survival and metabolism. The frequent aberrant activation of the PI 3-K/Akt pathway in human cancer has made it an attractive therapeutic target. Numerous studies have provided a comprehensive understanding of the specific functions of Akt signaling in cancer cells as well as the surrounding tumor microenvironment and this has informed and enabled the development of therapeutic drugs to target both PI 3-K and Akt. However, recent studies have provided evidence for distinct functions of the three mammalian Akt isoforms, particularly with respect to the regulation of cell motility and metastasis of breast cancer. Here we discus the mechanisms by which Akt signaling contributes to invasive migration and tumor metastasis, and highlight recent advances in our understanding of the contribution of the Akt pathway in the tumor-associated stroma.
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