Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort
Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort
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DOI：
10.1016/j.schres.2012.12.009
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发表时间：
2013-03-01
影响因子：
4.5
通讯作者：
Laurens, Kristin R.
中科院分区：
文献类型：
--
作者：
Downs, Johnny M.;Cullen, Alexis E.;Laurens, Kristin R.
背景：持续的精神病样经历（PLEs）与青春期内化症状的风险增加有关。这种关联是否同样适用于外部症状，以及从童年中期开始，尚不清楚。这项前瞻性研究调查了在何种程度上PLE持久性与内在化和外在化的精神病理学在一个社区样本的儿童年龄在9-11 years at study starting.Methods：8099儿童（平均年龄10.4岁）完成问卷调查评估PLE，外在化和内在化症状。一个子样本的547名儿童完成了重新评估，平均，两年后。结果：三分之二（66%）的儿童报告在基线的PLEs。大约两年后，这些儿童中有39%的人持续存在PLEs。在调整了先前的精神病理学和其他潜在的混淆因素后，持续性PLEs的儿童有更高的内在化风险，（比值比[OR]=1.94; 95%置信区间[CI] 1.13-3.34）和外部化（OR=1.97; 95%CI 1.19-3.26）精神病理学比儿童的PLEs缓解;和，比儿童从未提出PLEs。儿童中期的持续性PLEs与一般人群中后来的内化和外化精神病理学有关，而短暂的PLEs可能是规范的儿童发育谱的一部分。针对持续性PLEs的干预可能有助于减少常见的儿童精神病理学。(C)2012爱思唯尔有限公司版权所有。
Background: Persisting psychotic-like experiences (PLEs) are associated with an increased risk of internalising symptoms in adolescence. Whether this association holds similarly for externalising symptoms, and from mid-childhood, is unclear. This prospective study investigated the extent to which PLE persistence was associated with internalising and externalising psychopathology in a community sample of children aged 9-11 years at study commencement.Methods: 8099 children (mean age 10.4 years) completed questionnaires assessing PLEs, externalising and internalising symptoms. A subsample of 547 children completed reassessment, on average, two years later.Results: Two-thirds (66%) of children reported PLEs at baseline. Approximately two years later, PLEs persisted in 39% of those children. After adjustment for previous psychopathology and other potential confounds, children with persisting PLEs were at higher risk for internalising (odds ratio [OR]=1.94; 95% confidence interval [CI] 1.13-3.34) and externalising (OR=1.97; 95% CI 1.19-3.26) psychopathology than children whose PLEs remitted; and, than children who never presented PLEs.Conclusions: Persistent PLEs from mid-childhood are associated with later internalising and externalising psychopathology in the general population, whereas transitory PLEs may be part of a spectrum of normative childhood development. Interventions that target persistent PLEs may contribute to a reduction in common childhood psychopathology. (C) 2012 Elsevier B.V. All rights reserved.