Dopamine D2 receptors in the nucleus accumbens are important for social attachment in female prairie voles (Microtus ochrogaster).
Dopamine D2 receptors in the nucleus accumbens are important for social attachment in female prairie voles (Microtus ochrogaster).
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DOI：
10.1037//0735-7044.114.1.173
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发表时间：
2000-02
影响因子：
1.9
通讯作者：
B. Gingrich;Yan Liu;C. Cascio;Zuoxin Wang;T. Insel
中科院分区：
文献类型：
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作者：
B. Gingrich;Yan Liu;C. Cascio;Zuoxin Wang;T. Insel
草原田鼠（Microtus ochrogaster）是一种一夫一妻制的啮齿动物，可以形成持久的配对关系，已被证明对社会依恋的神经生物学研究很有用。在实验室中，可以通过测试伴侣偏好来评估配对关系，这是一种选择测试，在这种测试中，配对的田鼠经常喜欢他们的伴侣而不是同种陌生人。这里报道的研究调查了多巴胺D2样受体的作用（即，D2，D3和D4受体）在雌性田鼠的伴侣偏好的形成。交配促进了伴侣偏好的形成，并与NAcc中细胞外多巴胺增加约50%相关。微量注射的D2拮抗剂依替氯必利到NAcc（而不是前边缘皮层）阻止了形成的合作伙伴偏好在交配田鼠，而D2激动剂quinpirole促进形成的合作伙伴偏好在没有交配。两者合计，这些结果表明，D2样受体在NAcc是重要的调解社会附件在雌性田鼠。
The prairie vole (Microtus ochrogaster), a monogamous rodent that forms long-lasting pair bonds, has proven useful for the neurobiological study of social attachment. In the laboratory, pair bonds can be assessed by testing for a partner preference, a choice test in which pair-bonded voles regularly prefer their partner to a conspecific stranger. Studies reported here investigate the role of dopamine D2-like receptors (i.e., D2, D3, and D4 receptors) in the nucleus accumbens (NAcc) for the formation of a partner preference in female voles. Mating facilitated partner preference formation and associated with an approximately 50% increase in extracellular dopamine in the NAcc. Microinjection of the D2 antagonist eticlopride into the NAcc (but not the prelimbic cortex) blocked the formation of a partner preference in mating voles, whereas the D2 agonist quinpirole facilitated formation of a partner preference in the absence of mating. Taken together, these results suggest that D2-like receptors in the NAcc are important for the mediation of social attachments in female voles.