Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra
Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra
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DOI：
10.3858/emm.2010.42.12.085
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发表时间：
2010-12-31
影响因子：
12.8
通讯作者：
Joe, Eun-hye
中科院分区：
文献类型：
--
作者：
Jeong, Hey-Kyeong;Jou, Ilo;Joe, Eun-hye
有人提出，脑部炎症对于脑损伤的加重和/或炎症导致包括帕金森病（PD）在内的神经退行性疾病很重要。最近，全身炎症也成为帕金森病的危险因素。在本研究中，我们评估了静脉内（iv）脂多糖（LPS）注射诱导的全身炎症如何影响大鼠的脑炎症和神经元损伤。有趣的是，几乎所有的大脑炎症反应，包括小胶质细胞的形态激活、中性粒细胞浸润和炎症介质的mRNA/蛋白表达，都在多巴胺能神经元所在的黑质（SN）中在4-8小时内出现，并在1-3天内消退。然而，更重要的是，在静脉注射 LPS 后长达 8 天内未检测到多巴胺能神经元损失。总之，这些结果表明，全身炎症的急性诱导会导致脑部炎症，但这不足以引起神经元损伤。
It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson's disease (PD). Recently, systemic inflammation has also emerged as a risk factor for PD. In the present study, we evaluated how systemic inflammation induced by intravenous (iv) lipopolysaccharides (LPS) injection affected brain inflammation and neuronal damage in the rat. Interestingly, almost all brain inflammatory responses, including morphological activation of microglia, neutrophil infiltration, and mRNA/protein expression of inflammatory mediators, appeared within 4-8 h, and subsided within 1-3 days, in the substantia nigra (SN), where dopaminergic neurons are located. More importantly, however, dopaminergic neuronal loss was not detectable for up to 8 d after iv LPS injection. Together, these results indicate that acute induction of systemic inflammation causes brain inflammation, but this is not sufficiently toxic to induce neuronal injury.