Neuropilins in Tumor Biology
Neuropilins in Tumor Biology
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DOI：
10.1158/1078-0432.ccr-08-0563
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发表时间：
2009-03-15
影响因子：
11.5
通讯作者：
Watts, Ryan J.
中科院分区：
文献类型：
--
作者：
Bagri, Anil;Tessier-Lavigne, Marc;Watts, Ryan J.
神经匹林受体最初是作为神经系统发育的调节剂被发现的，它与丛蛋白一起作为信号蛋白共受体。随后，神经磷脂被鉴定为血管内皮生长因子的受体。自这些开创性的发现以来，已经描述了结合神经匹林的其他配体，并且许多研究表明神经匹林在肿瘤生物学中起着关键作用。最近的研究表明，控制神经匹林的功能可以通过影响神经匹林-1的血管生物学和神经匹林-2的淋巴生物学来调节肿瘤的生长和转移。神经匹林在肿瘤细胞中的直接作用也被假设。随着越来越多的数据指向神经匹林在癌症中的作用，靶向这一途径的前景开始显现。
The neuropilin receptors were first discovered as regulators of nervous system development, acting as semaphorin coreceptors with plexins. Subsequently, the neuropilins were identified as receptors for vascular endothelial growth factor. Since those seminal discoveries, additional ligands that bind neuropilins have been described, and many studies have implicated neuropilins in playing key roles in tumor biology. Recent evidence has shown that manipulating neuropilin function can regulate tumor growth and metastasis through effects on vascular biology in the case of neuropilin-1 and lymphatic biology in the case of neuropilin-2. A direct role for neuropilins within in tumor cells has also been postulated. As data continue to accumulate pointing to a role for neuropilins in cancer, the promise for targeting this pathway is beginning to unfold.