Comparison of the distribution of dynorphin systems and enkephalin systems in brain.
Comparison of the distribution of dynorphin systems and enkephalin systems in brain.
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强啡肽系统和脑啡肽系统在大脑中的分布比较。
DOI：
10.1126/science.6128790
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Goldstein,A
中科院分区：
文献类型：
--
作者：
Watson,SJ;Khachaturian,H;Akil,H;Coy,DH;Goldstein,A
内源性阿片样物质啡肽在大鼠脑内的解剖分布研究表明，该肽存在于一个广泛的系统中，具有多细胞群和多突起。该网络是通过使用多种抗啡肽血清揭示的，并且可以与含有蛋氨酸-脑啡肽和亮氨酸-脑啡肽的系统区分开来，后者是通过使用抗血清来绘制的，用于对抗脑啡肽和肾上腺中的生物合成相关肽。因此，大脑似乎包含至少三个独立的阿片神经网络：脑啡肽家族，其成分与肾上腺中发现的相似，β-内啡肽家族和肌啡肽家族。
A study of the anatomical distribution of the endogenous opioid dynorphin in rat brain showed that the peptide is localized in a widespread system with multiple cell groups and projections. This network is revealed by the use of multiple antiserums against dynorphin and can be distinguished from the system containing methionine-enkephalin and leucine-enkephalin, which is mapped by the use of antiserums against the enkephalins and biosynthetically related peptides in the adrenal. It thus appears that the brain contains at least three separate opioid neuronal networks: an enkephalin family with components similar to those found in the adrenal, a β-endorphin family, and a dynorphin family.