Inactivation of viruses in human cellular blood components.
Inactivation of viruses in human cellular blood components.
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人类细胞血液成分中病毒的灭活。
DOI：
10.1111/j.1423-0410.1994.tb04578.x
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发表时间：
1994
期刊：
影响因子：
2.7
通讯作者：
Corash,L
中科院分区：
文献类型：
--
作者：
Corash,L
尽管通过输血前广泛检测人类免疫缺陷病毒（HIV）、丙型肝炎病毒（HCV）、B肝炎病毒（HBV）和人类T细胞淋巴细胞病毒（HTLV I/II），已显著降低了病毒相关传染病通过输血的传播，但仍存在传播的剩余风险[1-6]。此外，其他病原体如疟疾寄生虫[2]、克氏锥虫[7]、巴氏锥虫[8]、细小病毒[2]和细菌[9]也未被当前的检测程序检测到。更重要的是，目前的检测策略无法检测出可能进入献血人群的未来病毒病原体;正如艾滋病毒一样，随着新病毒的出现，在进行敏感的筛选检测之前将有很大的延迟。因此，通过普遍灭活潜在病原体来净化血液制品的策略是有吸引力的。本讲座主要关注细胞血液制品中病毒病原体的灭活;然而，重要的是要记住，一个真正成功的通用去污方法应该能够灭活细菌和原生动物。在世界范围内，这是特别重要的，在许多地区，原生动物是输血获得性感染的重要贡献者。因此，在适当的情况下，将讨论处理这些病原体灭活的实验室研究。由于近年来大量的工作，本次审查将只提供一个概述目前的“最先进的”细胞血液成分的去污。更详细的资料可从最近一次会议的会议记录中获得[10]。病毒。
Although transmission of viral associated infectious diseases through blood transfusion has been markedly reduced by the implementation of extensive pre-transfusion donor testing for human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), and human T cell lymphotrophic virus (HTLV I/ll), there is still a residual risk of transmission [1-6]. In addition, other agents such as malaria parasites [2] Trypanosoma cruzi [7], babesia [8], parvovirus [2], and bacteria [9] are not detected by current testing programs. More importantly, future viral pathogens which may enter the donor population are undetected by the present testing strategy; and as with HIV, as new viruses emerge, there will be a substantial delay before sensitive screening tests can be implemented. Thus, a strategy to decontaminate blood products through the universal inactivation of potential pathogens is appealing. This lecture is primarily focused on inactivation of viral pathogens in cellular blood products; however, it is important to remember that a truly successful universal decontamination methodology should be capable of inactivating bacteria and protozoa in addition On a world-wide basis this is especially critical, in many regions protozoa are signifiant contributors to transfusion acquired infections. Thus, where appropriate, laboratory investigations dealing with inactivation of these pathogens will be discussed. Due to the large amount of work in recent years, this review will provide only an overview of the current “state of the art” of decontamination of cellular blood components. More detailed information may be obtained from the proceedings of a recent conference [10]. to viruses.