Long-term evaluation of patients with hydatidosis treated with benzimidazole carbamates
Long-term evaluation of patients with hydatidosis treated with benzimidazole carbamates
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DOI：
10.1086/520205
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发表时间：
1999-08-01
影响因子：
11.8
通讯作者：
Teggi, A
中科院分区：
文献类型：
--
作者：
Franchi, C;Di Vico, B;Teggi, A
448例细粒棘球绦虫包虫包虫患者接受甲苯咪唑或阿苯达唑连续治疗3~6个月，并通过临床随访和影像检查进行长期随访(1~14年)，以评价治疗的远期效果。退行性改变和复发通过影像技术进行评估。治疗结束时，74.1%的包虫囊有退行性改变。用阿苯达唑治疗的囊肿率比用甲苯咪唑治疗的囊肿率更高(82.2%比56.1%；P<；.001)。在长期随访中，104个(22%)囊变进展，而163个(约25%)囊变复发。两种药物处理过的汤的复发率几乎相同。复发更多地发生在II型肝囊肿。在治疗结束后的头两年内，囊肿复发最多(78.5%；P<；.001)。进一步的化疗周期可使90%的复发性囊肿发生退行性改变，而不会引起比最初化疗周期更频繁或更严重的副作用。
Four hundred forty-eight patients with 929 Echinococcus granulosus hydatid cysts received 3- to 6-month continuous cycles of mebendazole or albendazole treatment and underwent prolonged follow-up by clinical visits and imaging studies (range, 1-14 years) to assess the long-term outcome of treatment. Degenerative changes and relapse were assessed by imaging techniques. At the end of therapy, 74.1% of the hydatid cysts showed degenerative changes. These were more frequent in albendazole-treated than in mebendazole-treated cysts (82.2% vs. 56.1%; P < .001). During longterm follow-up, 104 cysts (22%) had degenerative changes that progressed, whereas 163 cysts (similar to 25%) relapsed. The percentages of relapses in the two drug-treated soups were almost the same. Relapses occurred more frequently in type II cysts of the liver. Cysts recurred most often (78.5%; P < .001) within the first 2 years after treatment ended. Further chemotherapy cycles induced degenerative changes in >90% of relapsed cysts without inducing more frequent or more severe side effects than those observed during the initial cycles.