Catalytic Enantioselective Synthesis of Planar-Chiral Cyclic Amides Based on a Pd-Catalyzed Asymmetric Allylic Substitution Reaction
Catalytic Enantioselective Synthesis of Planar-Chiral Cyclic Amides Based on a Pd-Catalyzed Asymmetric Allylic Substitution Reaction
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DOI：
10.1021/jacs.5b04340
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发表时间：
2015-06-17
影响因子：
15
通讯作者：
Tomooka, Katsuhiko
中科院分区：
文献类型：
--
作者：
Igawa, Kazunobu;Ichikawa, Nobumasa;Tomooka, Katsuhiko
在一定数量的手性配体存在下，通过钯催化的非手性线性前体的不对称烯丙基环化反应，实现了平面手性九元环酰胺的高对映选择性合成。
The highly enantioselective synthesis of planar-chiral nine-membered cyclic amides was achieved by the Pd-catalyzed asymmetric allylic cyclization of achiral linear precursors in the presence of a Catalytic amount of chiral ligand.