The fusion pore and vesicle cargo discharge modulation.
The fusion pore and vesicle cargo discharge modulation.
复制标题
融合孔和囊泡货物排放调节。
DOI：
10.1111/j.1749-6632.2008.04007.x
复制
发表时间：
2009
影响因子：
5.2
通讯作者：
Zorec,Robert
中科院分区：
文献类型：
--
作者：
Vardjan,Nina;Stenovec,Matjaz;Jorgacevski,Jernej;Kreft,Marko;Grilc,Sonja;Zorec,Robert
Exocytosis, the merger of the vesicle membrane with the plasma membrane, is thought to mediate the release of hormones and neurotransmitters from secretory vesicles. The work of Bernard Katz and colleagues decades ago considered that vesicle cargo discharge initially requires the delivery of secretory vesicles to the plasma membrane where vesicles dock and are primed for fusion with the plasma membrane. Then, upon stimulation, the vesicle and the plasma membranes fuse to form a transient fusion pore through which cargo molecules diffuse out of the vesicle lumen into the extracellular space. Katz and colleagues considered this process to occur in an all‐or‐none fashion. However, recent studies show that this may not be so simple. The aim of this overview is to highlight the novel findings that indicate that fusion pores are subject to regulations, which affect the release competence of a single vesicle. Here we discuss the elementary properties of spontaneous and stimulated peptidergic vesicle discharge, which appears to be modulated, at least in pituitary lactotrophs, by fusion pore conductance (pore diameter) and fusion pore gating (kinetics).
