Wnt1 overexpression promotes tumour progression in non-small cell lung cancer
Wnt1 overexpression promotes tumour progression in non-small cell lung cancer
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DOI：
10.1016/j.ejca.2008.08.004
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发表时间：
2008-11-01
影响因子：
8.4
通讯作者：
Ueno, Masaki
中科院分区：
文献类型：
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作者：
Huang, Cheng-Long;Liu, Dage;Ueno, Masaki
背景：Writ基因家族参与胚胎发生和肿瘤发生。我们研究了Wnt1在非小细胞肺癌（NSCLC）中表达的临床意义。方法：对216例非小细胞肺癌患者进行研究。免疫组化研究Wnt1表达与β -catenin和wnt靶点（包括c-Myc、Cyclin D1、VEGF-A和MMP-7）表达的关系。同时测定Ki-67增殖指数和瘤内微血管密度（IMD）。结果：wnt1阳性肿瘤中p -catenin异常表达率明显高于wnt1阴性肿瘤（p < 0.0001）。Wnt1表达与c-Myc （P < 0.0001）、Cyclin D1 （P < 0.0001）、VEGF-A （P = 0.0160）、MMP-7 （P < 0.0001）、Ki-67指数（P = 0.0048）、IMD （P = 0.0267）表达显著相关。此外，Wnt1状态是NSCLC患者预后的重要因素（p = 0.0127）。结论：在非小细胞肺癌中，Wnt1过表达与肿瘤相关wnt靶点的表达、肿瘤增殖、血管生成和不良预后有关。(C) 2008 Elsevier Ltd版权所有。
Background: The Writ gene family is involved in embryogenesis and tumourigenesis. We investigated the clinical significance of Wnt1 expression in non-small cell lung cancer (NSCLC).Method: We studied 216 NSCLC patients. immunohistochemistry was performed to investigate the Wnt1 expression in relation to the expression of beta-catenin and Wnt-targets, including c-Myc, Cyclin D1, VEGF-A and MMP-7. The Ki-67 proliferation index and the intratumoural microvessel density (IMD) were also evaluated.Results: The ratio of tumours with an aberrant P-catenin expression was significantly higher in Wnt1-positive tumours than in Wnt1-negative tumours (p < 0.0001). The Wnt1 expression significantly correlated with the expression of c-Myc (P < 0.0001), Cyclin D1 (p < 0.0001), VEGF-A (p = 0.0160), MMP-7 (p < 0.0001), the Ki-67 index (p = 0.0048) and the IMD (p = 0.0267). Furthermore, the Wnt1 status was a significant prognostic factor for NSCLC patients (p = 0.0127).Conclusions: The Wnt1 overexpression is associated with the expression of tumour-associated Wnt-targets, tumour proliferation, angiogenesis and a poor prognosis in NSCLCs. (C) 2008 Elsevier Ltd. All rights reserved.