Soluble Interleukin-2 Receptor Index Predicts Outcomes After Cord Blood Transplantation
Soluble Interleukin-2 Receptor Index Predicts Outcomes After Cord Blood Transplantation
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DOI：
10.1016/j.transproceed.2020.03.027
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发表时间：
2021-01-20
影响因子：
0.9
通讯作者：
Tanizawa, Yukio
中科院分区：
文献类型：
--
作者：
Kajimura, Yasuko;Nakamura, Yukinori;Tanizawa, Yukio
背景我们以前的研究表明，可溶性白细胞介素-2受体（sIL-2 R）指数，定义为中性粒细胞植入前血清sIL-2 R水平的比值，是一个生物标志物，可以预测非亲缘骨髓移植后急性移植物抗宿主病（GVHD）。在本研究中，我们评估了接受脐带血移植（CBT）的患者中sIL-2 R指标的意义。我们回顾性分析了31例首次接受单单位CBT的恶性血液病患者。中位sIL-2 R指数为4.2。II级至IV级急性GVHD的累积发生率与sIL-2 R指数无关。然而，移植后3年的累积复发率显著较低，sIL 2 R指数>= 3.7的患者比指数< 3.7的患者（12.8% vs 50.0%; P = 0.04）。结果表明，移植后3年总生存率前者明显高于后者（79.8%比20.0%; P
Background. Our previous study demonstrated that the soluble interleukin-2 receptor (sIL-2R) index, defined as the ratio of serum sIL-2R levels at neutrophil engraftment to that before conditioning, is a biomarker that can predict acute graft-vs-host disease (GVHD) after unrelated bone marrow transplantation. In the present study, we evaluated the significance of the sIL-2R index among patients who underwent cord blood transplantation (CBT).Methods. We retrospectively analyzed 31 patients who underwent single-unit CBT as their first transplantation for hematologic malignancies.Results. The median sIL-2R index was 4.2. The cumulative incidence of grade II to IV acute GVHD was not associated with the sIL-2R index. However, the cumulative incidence of relapse at 3 years after transplantation was significantly lower, with an sIL2R index >= 3.7 than with an index < 3.7 (12.8% vs 50.0%; P = .04). As a result, the probability of overall survival at 3 years after transplantation was significantly higher in the former group than in the latter (79.8% vs 20.0%; P