QUANTITATION OF THE HEPATIC ARTERIAL BUFFER RESPONSE TO GRADED CHANGES IN PORTAL BLOOD-FLOW
QUANTITATION OF THE HEPATIC ARTERIAL BUFFER RESPONSE TO GRADED CHANGES IN PORTAL BLOOD-FLOW
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DOI：
10.1016/0016-5085(90)90029-z
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发表时间：
1990-04-01
期刊：
影响因子：
29.4
通讯作者：
EZZAT, WR
中科院分区：
文献类型：
--
作者：
LAUTT, WW;LEGARE, DJ;EZZAT, WR
肝动脉血流量的变化与门静脉血流量的变化呈反比。肝动脉缓冲门脉血流变化的能力是在动脉压保持稳定（主动缓冲反应）或不受控制的门脉血流范围内研究的。缓冲反应的活性成分导致肝动脉在低门静脉流量下几乎完全扩张，如腺苷输注后无法进一步扩张所示;在高门静脉流量下，肝动脉几乎完全收缩，如去甲肾上腺素缺乏进一步收缩所示。在压力不受控制的情况下，主动和被动效应相结合以产生具有类似效率（44% ± 0.5%）的增加的补偿。4%）。因此，尽管肝动脉缓冲反应的主动成分在非常高和低的门静脉流量下变得不太有效，但是主动和被动效应的组合导致更大的缓冲能力，其在宽范围的门静脉血流变化上同样有效。
Hepatic arterial blood flow changes inversely in response to altered portal blood flow. The hepatic arterial capacity to buffer portal flow changes was studied over a wide range of portal flow with arterial pressure held steady (the active buffer response) or uncontrolled. The active component of the buffer response led to nearly full dilation of the hepatic artery at low portal flows as shown by inability to dilate further in response to adenosine infusion; at high portal flows the hepatic artery was nearly fully constricted as shown by lack of further constriction to norepinephrine. With pressure uncontrolled, active and passive effects combined to produce an increased compensation with similar efficiency (44% .+-. 4%) over the full range of portal blood flows. Thus, although the active component of the hepatic arterial buffer response becomes less efficient at very high and low portal flows, the combination of active and passive effects leads to a larger buffer capacity which is equally efficient over a wide range of portal blood flow changes.