SynechoNET: integrated protein-protein interaction database of a model cyanobacterium Synechocystis sp. PCC 6803.
SynechoNET: integrated protein-protein interaction database of a model cyanobacterium Synechocystis sp. PCC 6803.
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DOI：
10.1186/1471-2105-9-s1-s20
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发表时间：
2008
影响因子：
3
通讯作者：
Choi JS
中科院分区：
文献类型：
--
作者：
Kim WY;Kang S;Kim BC;Oh J;Cho S;Bhak J;Choi JS
蓝细菌是研究光合作用、碳氮同化、植物质体进化和对环境胁迫适应性的模式生物。尽管有许多研究蓝藻，有没有基于网络的数据库，其调控和信号蛋白质相互作用网络的日期。我们报告了一个数据库和网站SynechoNET，提供预测的蛋白质-蛋白质相互作用。SynechoNET显示了蓝藻结构域之间的相互作用，以及它们的蛋白质水平的相互作用，使用模型蓝藻，集胞藻属PCC 6803。它使用包含相互补充和冗余数据的公共相互作用数据库来预测蛋白质-蛋白质相互作用。此外，SynechoNET还提供了跨膜拓扑结构、信号肽和结构域结构的信息，以支持对调节膜蛋白的分析。这种生物信息可以在用户友好的网络界面中查询和可视化，该界面包括交互式网络查看器和按关键字和功能类别的搜索页面。SynechoNET是一个集成的蛋白质-蛋白质相互作用数据库，旨在分析蓝细菌中的调节膜蛋白。它为生物学家提供了一个平台，通过预测集胞藻蛋白的相互作用伙伴，膜缔合和膜拓扑结构来扩展蓝藻的基因组数据。SynechoNET可在或直接在免费获得。
Cyanobacteria are model organisms for studying photosynthesis, carbon and nitrogen assimilation, evolution of plant plastids, and adaptability to environmental stresses. Despite many studies on cyanobacteria, there is no web-based database of their regulatory and signaling protein-protein interaction networks to date. We report a database and website SynechoNET that provides predicted protein-protein interactions. SynechoNET shows cyanobacterial domain-domain interactions as well as their protein-level interactions using the model cyanobacterium, Synechocystis sp. PCC 6803. It predicts the protein-protein interactions using public interaction databases that contain mutually complementary and redundant data. Furthermore, SynechoNET provides information on transmembrane topology, signal peptide, and domain structure in order to support the analysis of regulatory membrane proteins. Such biological information can be queried and visualized in user-friendly web interfaces that include the interactive network viewer and search pages by keyword and functional category. SynechoNET is an integrated protein-protein interaction database designed to analyze regulatory membrane proteins in cyanobacteria. It provides a platform for biologists to extend the genomic data of cyanobacteria by predicting interaction partners, membrane association, and membrane topology of Synechocystis proteins. SynechoNET is freely available at or directly at .