Injectable Biodegradable Hydrogels
Injectable Biodegradable Hydrogels
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DOI：
10.1002/mabi.200900402
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发表时间：
2010-06-11
影响因子：
4.6
通讯作者：
Lee, Doo Sung
中科院分区：
文献类型：
--
作者：
Minh Khanh Nguyen;Lee, Doo Sung
可注射的可生物降解共聚物水凝胶，在响应外部刺激（如温度变化或pH值和温度（pH/温度）变化）时表现出溶胶-凝胶相变，在生物医学和制药应用中有许多用途，如药物输送、细胞生长和组织工程。这些水凝胶可用于简单的药物制剂，可通过将水凝胶与药物、蛋白质或细胞混合来制备。这样的配方通过对释放行为的位点特异性控制以直接的方式施用，并且水凝胶与生物系统兼容。本文综述了可生物降解的温度敏感聚合物的最新进展，包括聚酯、聚磷腈、多肽和壳聚糖，以及pH/温度敏感聚合物，如磺胺乙嗪-、聚-氨基酯-、聚氨基甲酸乙酯-和聚（氨基胺）基聚合物。还讨论了pH/温度敏感聚合物相对于简单温度敏感聚合物的优点。展望了可注射生物可降解水凝胶的未来。
Injectable biodegradable copolymer hydrogels, which exhibit a sol gel phase transition in response to external stimuli, such as temperature changes or both pH and temperature (pH/temperature) alterations, have found a number of uses in biomedical and pharmaceutical applications, such as drug delivery, cell growth, and tissue engineering. These hydrogels can be used in simple pharmaceutical formulations that can be prepared by mixing the hydrogel with drugs, proteins, or cells. Such formulations are administered in a straightforward manner, through site-specific control of release behavior, and the hydrogels are compatible with biological systems. This review will provide a summary of recent progress in biodegradable temperature-sensitive polymers including polyesters, polyphosphazenes, polypeptides, and chitosan, and pH/temperature-sensitive polymers such as sulfamethazine-, poly(beta-amino ester)-, poly(amino urethane)-, and poly(amidoamine)-based polymers. The advantages of pH/temperature-sensitive polymers over simple temperature-sensitive polymers are also discussed. A perspective on the future of injectable biodegradable hydrogels is offered.