Changes in circulating inhibin levels during pregnancy and early lactation in the Japanese monkey.
Changes in circulating inhibin levels during pregnancy and early lactation in the Japanese monkey.
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日本猴怀孕期间和哺乳早期循环抑制素水平的变化。
DOI：
10.1095/biolreprod43.3.444
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发表时间：
1990
影响因子：
3.6
通讯作者：
K. Oshima
中科院分区：
文献类型：
--
作者：
M. Nozaki;G. Watanabe;K. Taya;Y. Katakai;I. Wada;S. Sasamoto;K. Oshima
采用基于牛放射免疫分析法（RIA）对6只日本猕猴（Macaca fuscata fuscata）血清免疫反应性（ir-）抑制素浓度在妊娠和哺乳期早期至分娩后1个月的变化进行了研究。在整个研究期间，还监测了血清FSH、LH/猴绒毛膜促性腺激素（mCG）、雌二醇-17 β和孕酮的水平。妊娠前血清il -抑制素水平较低（低于0.5 ng/ml）。在怀孕期间，血清中il -抑制素水平有三个显著的升高。第一次增加出现在妊娠早期，在妊娠第22天达到峰值（2.2 +/- 0.2 ng/ml）（第0天= LH激增日）。第二次升高发生在妊娠第38天至第72天，峰值为19.0 +/- 1.4 pg/ml。平台水平一直维持到妊娠晚期，并在妊娠第158天（分娩前5天）达到峰值（36.7 +/- 3.8 ng/ml），最终在足月附近明显上升。分娩后，血清中il -抑制素水平在一天内骤降至非妊娠水平，并在哺乳期早期维持。妊娠期血清抑制素第一次升高与mCG和雌二醇-17 β升高平行，第二次和第三次升高与血清雌二醇-17 β升高密切相关。妊娠期间血清FSH维持在低水平，分娩后血清抑制素骤降，FSH略有升高。在妊娠120天的胎盘匀浆中检测抑制素的生物活性和免疫反应性。（摘要删节250字）
Changes in immunoreactive (ir-) inhibin concentrations in serum throughout pregnancy and early lactation up to one month after parturition were characterized in 6 Japanese monkeys (Macaca fuscata fuscata) by a heterologous radioimmunoassay (RIA) based on a bovine RIA. Serum levels of FSH, LH/monkey chorionic gonadotropin (mCG), estradiol-17 beta, and progesterone were also monitored for the entire period. Ir-inhibin levels in the serum were low (under 0.5 ng/ml) before conception. Three marked increases in serum ir-inhibin levels were found during pregnancy. The first increase was noted during early pregnancy, with a peak (2.2 +/- 0.2 ng/ml) at Day 22 of pregnancy (Day 0 = day of LH surge). The second increase was noted after Day 38 until Day 72 of pregnancy, when a peak value was noted (19.0 +/- 1.4 pg/ml). Plateau levels were maintained until late pregnancy, and a final rise was evident near the term with a peak (36.7 +/- 3.8 ng/ml) at Day 158 of pregnancy, 5 days before parturition. After parturition, ir-inhibin levels in the serum plummeted to nonpregnant levels within one day, and were maintained during early lactation. The first rise in serum inhibin during pregnancy was parallel to the rise of mCG and estradiol-17 beta, and the second and third rise were well correlated with serum estradiol-17 beta. Serum FSH was maintained at low levels throughout pregnancy, followed by a slight increase after parturition when serum inhibin decreased abruptly. Both bioactivity and immunoreactivity of inhibin were detected in the placental homogenates obtained at 120 days of pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS)
灵长类动物卵巢内抑制素/激活素亚基 mRNA 的定位。
DOI：
10.1210/mend-4-1-75
发表时间：
1990
期刊：
Molecular endocrinology (Baltimore, Md.)
影响因子：
--
作者：
Schwall,RH;Mason,AJ;Wilcox,JN;Bassett,SG;Zeleznik,AJ
通讯作者：
Zeleznik,AJ