Prevalence of sexual dimorphism in mammalian phenotypic traits.
Prevalence of sexual dimorphism in mammalian phenotypic traits.
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DOI：
10.1038/ncomms15475
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发表时间：
2017-06-26
影响因子：
16.6
通讯作者：
White JK
中科院分区：
文献类型：
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作者：
Karp NA;Mason J;Beaudet AL;Benjamini Y;Bower L;Braun RE;Brown SDM;Chesler EJ;Dickinson ME;Flenniken AM;Fuchs H;Angelis MH;Gao X;Guo S;Greenaway S;Heller R;Herault Y;Justice MJ;Kurbatova N;Lelliott CJ;Lloyd KCK;Mallon AM;Mank JE;Masuya H;McKerlie C;Meehan TF;Mott RF;Murray SA;Parkinson H;Ramirez-Solis R;Santos L;Seavitt JR;Smedley D;Sorg T;Speak AO;Steel KP;Svenson KL;International Mouse Phenotyping Consortium;Wakana S;West D;Wells S;Westerberg H;Yaacoby S;White JK
性在生物医学研究中的作用经常被忽视，尽管在一些生物学研究中有证据表明性的二态效应。在这里，我们使用了来自14，250只野生型和40，192只突变小鼠（代表2，186个敲除系）的高通量表型数据，分析了多达234个性状，发现野生型和突变体中大部分哺乳动物性状都受到性别的影响。这一结果对解释动物模型和人类的疾病表型具有意义。缺乏对小鼠性二态表型的系统解剖。在这里，卡普和国际小鼠表型联盟表明，在实验室环境中测量的小鼠中大约10%的定性性状和56%的定量性状是性二态的。
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans. Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory setting are sexually dimorphic.