Deregulated microRNAs and Adiponectin in Postmenopausal Women with Breast Cancer
Deregulated microRNAs and Adiponectin in Postmenopausal Women with Breast Cancer
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DOI：
10.1159/000496340
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发表时间：
2019-01-01
影响因子：
2.1
通讯作者：
Lopez, Adriana
中科院分区：
文献类型：
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作者：
Isabel Pena-Cano, Maria;Saucedo, Renata;Lopez, Adriana
背景：肥胖是乳腺癌(BC)的危险因素。肥胖导致癌症发展的一些机制是胰岛素样生长因子(IGF)、脂肪因子和microRNAs(MiRs)。本研究的目的是确定miR-17-5p、miR-195-5p和miR-2213p在肥胖和非肥胖绝经后BC患者的血清样本中的表达是否被解除调节。并对胰岛素、脂联素、瘦素、胰岛素样生长因子进行分析。方法：对50例初诊为BC的绝经后妇女和50例绝经后健康妇女进行评估。分析了BC患者与健康患者、肥胖患者与瘦患者之间MIR的差异。建立了MIR的受试者操作特征曲线，用于区分有无BC的患者，并研究了MIR、脂肪因子和乳腺肿瘤特征之间的关系。结果：BC患者血清miR-17-5p和miR-195-5p水平明显高于对照组，miR-221-3p和脂联素水平显著低于对照组。MiR-195-5p水平升高使BC与对照组的敏感度和特异度分别为83.3%和78.3%，并与小叶癌和低分化癌相关。肥胖组和瘦肉组之间的MIR水平没有差异。结论：绝经后BC患者循环MIR和脂联素水平降低。(C)2019年S.Karger AG，巴塞尔
Background: Obesity is a risk factor for breast cancer (BC). Some mechanisms through which obesity can lead to cancer development are insulin-like growth factors (IGFs), adipokines, and microRNAs (miRs). The objective of the study was to determine whether miR-17-5p, miR-195-5p, and miR-2213p expressions were deregulated in serum samples of obese and nonobese postmenopausal women with BC. In addition, insulin, adiponectin, leptin and IGFs were analyzed. Methods: Fifty postmenopausal women with newly diagnosed BC and 50 postmenopausal healthy women were evaluated. Differences in miRs between BC and healthy cases and between obese and lean participants were analyzed. Receiver operating characteristic curves for miRs for discriminating patients with or without BC were established, and relationships between the miRs, adipokines, and breast tumor characteristics were also investigated. Results: miR-17-5p and miR-195-5p were higher in patients with BC in comparison to the controls, while miR-221-3p and adiponectin were significantly lower. Increased levels of miR-195-5p allowed the differentiation of BC from controls with a sensitivity of 83.3 and a specificity of 78.3%, and were associated with lobular and poorly differentiated cancer. There was no difference in miRs levels between obese and lean groups. Conclusions: Circulating miRs and adiponectin were deregulated in postmenopausal women with BC. (C) 2019 S. Karger AG, Basel