Amplified cardiorespiratory activity by hypoxia in conscious spontaneously hypertensive rats
Amplified cardiorespiratory activity by hypoxia in conscious spontaneously hypertensive rats
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清醒自发性高血压大鼠缺氧增强心肺活动
DOI：
10.13294/j.aps.2019.0023
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发表时间：
2019
影响因子：
--
通讯作者：
Sheng Wang
中科院分区：
文献类型：
--
作者：
Yan-Ming Tian;Lan Ma;Dan-Yang Geng;Fang Yuan;Yi Zhang;Sheng Wang
外周呼吸化学感受器的激活引起呼吸和心血管反射，为高血压的发病机制提供了新的认识。在此，我们假设缺氧激活外周呼吸化学感受器导致清醒自发性高血压大鼠（SHR）心肺活动增强。采用全身体积描记结合无线电遥测技术，对自发性高血压大鼠（SHR）和Wistar-Kyoto（WKY）大鼠的肺通气、动脉血压和心率进行了检测。我们发现，暴露于缺氧诱导更大的增加潮气量和分钟通气量在SHR相比，WKY大鼠。此外，缺氧引起了一个强大的增加动脉血压和心率在SHR相对于WKY同行。去颈动脉体神经后，SHR和WKY大鼠的低氧刺激反应均明显降低，但两种品系之间差异无统计学意义; SHR和WKY大鼠在低氧暴露期间的动脉血压和心率变化差异无统计学意义。结果表明，低氧可显著增强自发性高血压大鼠的心肺活动，提示颈动脉体对低氧的敏感性增强。
Activation of peripheral respiratory chemoreceptors provokes respiratory and cardiovascular reflexes, providing a novel understanding of pathogenic mechanism of hypertension. Here we hypothesize that activation of peripheral respiratory chemoreceptors by hypoxia causes enhanced cardiorespiratory activity in conscious spontaneously hypertensive rats (SHRs). Using whole body plethysmography in combination with radio telemetry, pulmonary ventilation, arterial blood pressure and heart rate were examined in SHRs and Wistar-Kyoto (WKY) rats. We found that exposure to hypoxia induced greater increases in tidal volume and minute ventilation volume in SHRs compared to WKY rats. In addition, hypoxia caused a robust increase in arterial blood pressure and heart rate in SHRs relative to WKY counterparts. After carotid body denervation, the hypoxic ventilatory response was significantly decreased in both SHRs and WKY rats, but without significant difference between the two strains; moreover, the differences of arterial blood pressure and heart rate changes during hypoxic exposure were statistically insignificant between SHRs and WKY rats. It is concluded that hypoxia remarkably potentiates cardiorespiratory activity in the SHRs, suggesting an enhanced sensitivity of carotid bodies to hypoxia.