Acute dystonic reaction in an elderly patient with mood disorder after titration of paroxetine: possible mechanisms and implications for clinical care
Acute dystonic reaction in an elderly patient with mood disorder after titration of paroxetine: possible mechanisms and implications for clinical care
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DOI：
10.1177/026988110201600418
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发表时间：
2002-12-01
影响因子：
4.1
通讯作者：
Kerr, JS
中科院分区：
文献类型：
--
作者：
Arnone, D;Hansen, L;Kerr, JS
如文献所述，5-羟色胺再摄取抑制剂给药可能导致锥体外系体征。老年人的风险似乎增加了。我们描述一位患有双相情感障碍的老年患者，在接受帕罗西汀治疗后发生急性张力障碍反应。潜在的机制，可能产生于皮层下运动区，与发生在药代动力学变量的变化，老化神经元的神经可塑性降低和以前暴露于抗精神病药物有关。
The administration of a serotonin reuptake inhibitor may lead to extra pyramidal signs, as reported in the literature. The risk seems to be increased in elderly people. We describe a case of acute dystonic reaction to paroxetine treatment in art elderly patient, who presented with a bipolar affective disorder. The underlying mechanism, possibly generated in the subcortical motor areas, is linked to changes that occur in the pharmacokinetic variables, the decreased neuroplasticity of ageing neurones and to previous exposure to neuroleptic medications.