Unite to divide: Oligomerization of tubulin and actin homologs regulates initiation of bacterial cell division.
Unite to divide: Oligomerization of tubulin and actin homologs regulates initiation of bacterial cell division.
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DOI：
10.12688/f1000research.13504.1
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Margolin W
中科院分区：
文献类型：
--
作者：
Krupka M;Margolin W
为了从一个细胞生成两个细胞，大肠杆菌等细菌使用一种称为分裂体的膜内蛋白质复合物来合成分裂隔。细胞质分裂的初始阶段需要微管蛋白同源物FtsZ，它在细胞周长周围形成聚合物。这些聚合物附着在细胞质膜上需要肌动蛋白同源物FtsA，它也形成直接与FtsZ结合的动态聚合物。最近的证据表明，在大肠杆菌中，FtsA和FtsZ相互调节彼此的寡聚物状态，以控制细胞分裂的进程，包括隔膜合成蛋白的募集。在这篇综述中，我们重点介绍了FtsZ和FtsA在分裂功能初始阶段的蛋白-蛋白关联的最新进展，主要是在已经被充分表征的大肠杆菌系统中。
To generate two cells from one, bacteria such as Escherichia coli use a complex of membrane-embedded proteins called the divisome that synthesize the division septum. The initial stage of cytokinesis requires a tubulin homolog, FtsZ, which forms polymers that treadmill around the cell circumference. The attachment of these polymers to the cytoplasmic membrane requires an actin homolog, FtsA, which also forms dynamic polymers that directly bind to FtsZ. Recent evidence indicates that FtsA and FtsZ regulate each other’s oligomeric state in E. coli to control the progression of cytokinesis, including the recruitment of septum synthesis proteins. In this review, we focus on recent advances in our understanding of protein-protein association between FtsZ and FtsA in the initial stages of divisome function, mainly in the well-characterized E. coli system.