Insecticide mixtures for mosquito net impregnation against malaria vectors
Insecticide mixtures for mosquito net impregnation against malaria vectors
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DOI：
10.1051/parasite/2002093255
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发表时间：
2002-09-01
期刊：
影响因子：
2.9
通讯作者：
Hougard, JM
中科院分区：
文献类型：
--
作者：
Corbel, V;Darriet, F;Hougard, JM
属于拟除虫菊酯家族的杀虫剂是目前唯一可用于处理蚊帐的化合物。不幸的是，一些疟疾病媒物种已经对拟除虫菊酯产生了抗药性，并且缺乏替代化学类别是一个令人非常担忧的问题。抗药性管理的一种策略是用两种具有不同作用方式的杀虫剂的混合物来处理蚊帐。本研究介绍了使用含有多种比例的联苯菊酯（一种拟除虫菊酯杀虫剂）和丁硫克百威（一种氨基甲酸酯杀虫剂）的杀虫剂混合物获得的结果。将混合物喷洒在蚊帐样本上，并针对冈比亚按蚊（非洲主要疟疾媒介）敏感菌株测试其功效。使用含有 25 mg/m(2) 联苯菊酯（处理网推荐剂量的一半）和 6.25 mg/m(2) 丁硫克百威（约推荐剂量的 2%）的混合物观察到显着的协同作用。在没有任何相互作用的情况下，观察到的死亡率明显高于预期（80% vs 41%），并且击倒效应得以维持，为抵抗易感蚊子提供了有效的屏障。
Insecticides belonging to the pyrethroid family are the only compounds currently available for the treatment of mosquito nets, Unfortunately, some malaria vector species have developed resistance to pyrethroids and the lack of alternative chemical categories is a great concern. One strategy for resistance management would be to treat mosquito nets with a mixture associating two insecticides having different modes of action. This study presents the results obtained with insecticide mixtures containing several proportions of bifenthrin a pyrethroid insecticide) and carbosulfan (a carbamate insecticide). The mixtures were sprayed on mosquito net samples and their efficacy were tested against a susceptible strain of Anopheles gambiae, the major malaria vector in Africa. A significant synergism was observed with a mixture containing 25 mg/m(2) of bifenthrin (half the recommended dosage for treated nets) and 6.25 mg/m(2) of carbosulfan (about 2 % of the recommended dosage). The observed mortality was significantly more than expected in the absence of any interaction (80 % vs 41 %) and the knock-down effect was maintained, providing an effective barrier against susceptible mosquitoes.