Long Noncoding RNAs in Cancer and Therapeutic Potential
Long Noncoding RNAs in Cancer and Therapeutic Potential
复制标题
DOI：
10.1007/978-981-10-5203-3_7
复制
发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Felley-Bosco, Emanuela
中科院分区：
文献类型：
--
作者：
Renganathan, Arun;Felley-Bosco, Emanuela
长链非编码RNA（lncRNA）是哺乳动物转录组的主要组成部分，正在成为控制多种细胞机制的核心参与者。迄今为止，大多数研究充分的lncRNA被发现在调节细胞过程中至关重要，如细胞周期，生长和凋亡，以确保稳态。由于它们在基因组中的位置和分布，lncRNA通过转录和转录后改变直接或间接地影响多种蛋白质的转录，这以上下文依赖的方式打开了“LncRNA-癌症范例”，即，致癌的或肿瘤抑制的。因此，本章是一个巩固lncRNA协会在展示或抑制典型的癌症标志，如持续增殖，超越凋亡，基因组不稳定性，耐药性，侵袭和转移研究至今。此外，特别关注lncRNA作为治疗剂的潜在靶点的有效应用，这对未来的癌症治疗有很大的希望。
Long noncoding RNAs (lncRNAs) are the major elements of the mammalian transcriptome that is emerging as a central player controlling diverse cellular mechanisms. Most of the well-studied lncRNAs so far are found to be crucial in regulating cellular processes such as cell cycle, growth, and apoptosis that ensure homeostasis. Owing to their location and distribution in the genome, lncRNAs influence the transcription of a wide range of proteins directly or indirectly by transcriptional and posttranscriptional alterations, which opens up the "LncRNA-cancer paradigm" in a context-dependent manner, i.e., either oncogenic or tumor suppressive. Thus, this chapter is a consolidation of lncRNA association in exhibiting or suppressing the typical cancer hallmarks such as continuous proliferation, surpassing apoptosis, genomic instability, drug resistance, invasion, and metastasis studied till date. In addition, special focus has been given on the efficient application of lncRNAs as potential targets for therapeutics that holds a great promise for future cancer therapy.