REDUCTIONS IN ARTERIAL DIAMETER PRODUCED BY CHRONIC DECREASES IN BLOOD-FLOW ARE ENDOTHELIUM-DEPENDENT
REDUCTIONS IN ARTERIAL DIAMETER PRODUCED BY CHRONIC DECREASES IN BLOOD-FLOW ARE ENDOTHELIUM-DEPENDENT
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DOI：
10.1126/science.3941904
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发表时间：
1986-01-24
期刊：
影响因子：
56.9
通讯作者：
ODONNELL, F
中科院分区：
文献类型：
--
作者：
LANGILLE, BL;ODONNELL, F
兔颈总动脉血流速度下降70%，导致该动脉直径在两周内减少21%。平滑肌松弛药罂粟碱不能减弱这种反应；因此，这种直径的缩小可能反映了动脉壁的结构改变，而不是平滑肌的持续收缩。当血管内皮细胞被移除时，这种动脉对血流减少的反应被取消。血管内皮细胞对于动脉对管腔血流速度长期变化的代偿性反应是必不可少的。
A 70 percent reduction in the rate of blood flow through the common carotid artery in rabbits caused a 21 percent decrease in the diameter of this artery within 2 weeks. The smooth muscle relaxant papaverine did not attenuate the response; therefore, such reductions in diameter probably reflect a structural modification of the arterial wall rather than sustained contraction of smooth muscle. This arterial response to reduced blood flow was abolished when the endothelium was removed from the vessels. It appears that the endothelium is essential for the compensatory arterial response to long-term changes in luminal blood flow rates.