Determination of bile acid concentration in human amniotic fluid for prenatal diagnosis of intestinal obstruction.
Determination of bile acid concentration in human amniotic fluid for prenatal diagnosis of intestinal obstruction.
复制标题
测定人羊水中胆汁酸浓度用于产前诊断肠梗阻。
DOI：
10.1097/00006254-197801000-00014
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发表时间：
1977
期刊：
影响因子：
8
通讯作者：
G. Paumgartner
中科院分区：
文献类型：
--
作者：
G. Délèze;D. Sidiropoulos;G. Paumgartner
从11例无羊水过多的健康孕妇（妊娠28 ~ 42周）和9例羊水过多的患者（妊娠28 ~ 38周）的标准适应症中采集羊水，测定胆汁酸浓度。后两名妇女分娩的婴儿患有法特氏乳头远端肠梗阻，这是一种导致胆汁回流到羊水中的疾病。在没有羊水过多的妇女中，总胆汁酸浓度范围为1.4至2.4微摩尔/升。在7例羊水过多与胎儿肠梗阻无关的患者中，羊水中的胆汁酸浓度没有显著差异（0.9至1.9微摩尔/升）。相比之下，两名羊水过多患者的羊水样本中胆汁酸浓度显著升高（30.3至83.1微摩尔/升），这些患者生下了肠梗阻儿童。这些结果表明，羊水中胆汁酸浓度的测定允许产前诊断远端的乏特氏乳头肠梗阻。
Bile acid concentration was measured in amniotic fluid obtained for standard indications from 11 healthy pregnant women without polyhydramnios (28 to 42 weeks of gestation) and from 9 patients with polyhydramnios (28 to 38 weeks of gestation). Two of the latter women delivered infants with intestinal obstruction distal to the papilla of Vater, a condition that causes regurgitation of bile into the amniotic fluid. In the women without polyhydramios, the total bile acid concentration ranged from 1.4 to 2.4 micronmol/liter. In the seven patients with polyhydramnios not associated with fetal intestinal obstruction, the bile acid concentration in amniotic fluid was not significantly different (0.9 to 1.9 micronmol/liter). By contrast, the bile acid concentration in amniotic fluid specimens from the two patients with polyhydramnios who gave birth to children with intestinal obstruction was considerably elevated (30.3 to 83.1 micronmol/liter). These findings suggest that determination of bile acid concentration in amniotic fluid permits prenatal diagnosis of intestinal obstruction distal to the papilla of Vater.