Heterogeneity of Diffusion-Weighted Imaging in Tumours and the Surrounding Stroma for Prediction of Ki-67 Proliferation Status in Breast Cancer.
Heterogeneity of Diffusion-Weighted Imaging in Tumours and the Surrounding Stroma for Prediction of Ki-67 Proliferation Status in Breast Cancer.
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肿瘤和周围基质弥散加权成像的异质性用于预测乳腺癌 Ki-67 增殖状态
DOI：
10.1038/s41598-017-03122-z
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发表时间：
2017-06-06
影响因子：
4.6
通讯作者：
Li L
中科院分区：
文献类型：
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作者：
Fan M;He T;Zhang P;Zhang J;Li L
乳腺组织异质性与导致肿瘤生长更具侵袭性和预后更差的风险因素有关，但这种异质性尚未得到很好的表征。本研究的目的是揭示肿瘤及其周围间质组织的表观扩散系数（ADC）的异质信号模式，并预测雌激素受体（ER）阳性乳腺癌患者的Ki-67增殖状态。收集了82例接受弥散加权成像（DWI）检查的患者的数据集。ADC图被分割成包括肿瘤和周围基质壳的区域。为了反映每个区域在其平均ADC值方面的相关性，构建了由作为区域的节点和作为两个节点之间的相互作用的边缘组成的功能图。对该图的分析揭示了过度表达Ki-67的样品中的平均程度高于具有低Ki-67表达的样品。在低Ki-67组中，大多数识别的边缘表示相邻区域之间的相关性，而在高Ki-67组中发现了表示非相邻区域之间的相关性的额外边缘。在不同的乳腺间质区域周围的肿瘤的ADC信号表现出一种歧视性的模式，将是有价值的估计Ki-67增殖状态的DWI。
Breast tissue heterogeneity is related to risk factors that lead to more aggressive tumour growth and worse prognosis, yet such heterogeneity has not been well characterized. The aim of this study is to reveal the heterogeneous signal patterns of the apparent diffusion coefficient (ADC) of a tumour and its surrounding stromal tissue and to predict the Ki-67 proliferation status in oestrogen receptor (ER)-positive breast cancer patients. A dataset of 82 patients who underwent diffusion-weighted imaging (DWI) examination was collected. The ADC map was segmented into regions comprising the tumour and the surrounding stromal shells. To reflect correlations between each region in terms of its mean ADC value, a functional graph was constructed consisting of nodes as regions and edges as interactions between two nodes. Analysis of the graph revealed a higher average degree in samples over-expressing Ki-67 than in samples with low Ki-67 expression. In the low-Ki-67 group, most of the identified edges represented correlations between adjacent regions, whereas additional edges representing correlations between non-adjacent regions were found in the high-Ki-67 group. The ADC signal in various breast stromal regions surrounding the tumour showed a discriminative pattern and would be valuable for estimating the Ki-67 proliferation status by DWI.