Dihydrotestosterone inhibits murine hair growth via the androgen receptor
Dihydrotestosterone inhibits murine hair growth via the androgen receptor
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DOI：
10.1111/j.1365-2133.2008.08671.x
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发表时间：
2008-08-01
影响因子：
10.3
通讯作者：
Ohdera, M.
中科院分区：
文献类型：
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作者：
Naito, A.;Sato, T.;Ohdera, M.
雄激素导致顶额部头皮毛囊退化，但其确切机制尚不清楚。目的利用雄激素受体敲除（ARKO）小鼠研究雄激素对小鼠毛发生长和毛发周期的影响。方法利用ARKO小鼠和野生型（WT）小鼠，观察双氢睾酮（DHT）对毛发生长的影响，并探讨其作用机制。通过组织学和组织形态计量学比较ARKO小鼠和WT小鼠的毛发周期，并测量ARKO小鼠和WT小鼠的毛发长度和厚度。在第二毛发周期中，ARKO小鼠的毛发生长期长于其WT同窝小鼠。结论雄激素抑制小鼠毛发生长，这种抑制作用可能是通过雄激素-雄激素受体信号引起的。
Background Androgens cause regression of human hair follicles in the parietofrontal scalp, but the precise mechanisms by which they do so are unknown. Although many investigators have elucidated the effect of androgens on hair growth by using rodents and other animals, some of the evidence is conflicting.Objectives To investigate the effect of androgens on mouse hair regrowth and hair cycle by using androgen receptor knockout (ARKO) mice.Methods We examined the effects of dihydrotestosterone (DHT) on hair regrowth by using ARKO mice and wild-type (WT) littermates, compared the hair cycles in ARKO mice and WT littermates by histology and histomorphometry, and measured hair length and thickness in ARKO mice and WT littermates.Results DHT inhibited the hair regrowth of WT mice but not that of their ARKO littermates. The anagen phase in the second hair cycle was longer in ARKO mice than in their WT littermates. The hair of ARKO mice was longer and thicker than that of their WT littermates.Conclusions Androgens inhibit hair growth in mice, and this inhibition might be caused by androgen-androgen receptor signals.