Human neutrophils dump Candida glabrata after intracellular killing
Human neutrophils dump Candida glabrata after intracellular killing
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DOI：
10.1016/j.fgb.2015.09.008
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发表时间：
2015-11-01
影响因子：
3
通讯作者：
Kurzai, Oliver
中科院分区：
文献类型：
--
作者：
Essig, Fabian;Huenniger, Kerstin;Kurzai, Oliver
真菌病原体和人类吞噬细胞之间的相互作用可以导致显著可变的结果，从细胞内杀伤到病原体在宿主细胞中的延长存活和复制。使用活细胞成像，我们观察到原代人中性粒细胞在细胞内杀伤后释放吞噬光滑念珠菌酵母细胞。这个过程中，我们提出的名称为“倾倒”，增加了一个新的结果吞噬细胞-真菌的相互作用，这可能是潜在的免疫学的重要性，因为它允许专业的抗原呈递细胞采取和处理嗜热菌灭活的病原体，在其可行的状态是能够逃避这些细胞的细胞内降解。(C)2015爱思唯尔公司All rights reserved.
Interaction between fungal pathogens and human phagocytes can lead to remarkably variable outcomes, ranging from intracellular killing to prolonged survival and replication of the pathogen in the host cell. Using live cell imaging we observed primary human neutrophils that release phagocytosed Candida glabrata yeast cells after intracellular killing. This process, for which we propose the name "dumping", adds a new outcome to phagocyte-fungus interaction which may be of potential immunological importance as it allows professional antigen presenting cells to take up and process neutrophil-inactivated pathogens that in their viable state are able to evade intracellular degradation in these cells. (C) 2015 Elsevier Inc. All rights reserved.