Microvascular alterations in the one-kidney, one-clip renal hypertensive rat.
Microvascular alterations in the one-kidney, one-clip renal hypertensive rat.
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单肾、单夹肾高血压大鼠的微血管改变。
DOI：
10.1152/ajpheart.1984.246.5.h728
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Dowell,RF
中科院分区：
文献类型：
--
作者：
Prewitt,RL;Chen,II;Dowell,RF
本实验观察了单肾一夹肾性高血压大鼠（1 KG）和单肾切除对照组术后4-6周和8-10周的微循环变化。在氯醛糖-乌拉坦麻醉下，用光管原位透照股薄肌。在三个连续的状态下测量小动脉和毛细血管密度和小动脉直径：神经支配，去神经支配和用硝普钠舒张血管。血管舒张后测量小动脉壁腔比。在4-6周，1 KG组的血管收缩显著更大，血管舒张的小动脉直径显著更小，部分原因是壁腔比升高。与对照组相比，在神经支配和去神经支配状态下，1 KG中的毛细血管密度降低。1 KG组8-10周时，小动脉收缩反应不再明显增强。然而，血管舒张的小动脉直径较小，壁腔比进一步增加，小动脉和毛细血管稀疏。因此，随着时间的推移，增加血管阻力的结构机制被认为取代了血管收缩的主动机制。
The microcirculation was studied in one-kidney, one-clip renal hypertensive rats ( 1KG ) and uninephrectomized controls at 4-6 and 8-10 wk postoperation. Under chloralose-urethan anesthesia the gracilis muscle was transilluminated in situ with a light pipe. Measurements of arteriolar and capillary density and arteriolar diameter were made in three consecutive states: innervated, denervated, and vasodilated with nitroprusside. Arteriolar wall-to-lumen ratio was measured after vasodilation. At 4-6 wk vasoconstriction was significantly greater in 1KG and vasodilated arteriolar diameter was significantly smaller, partially because of an elevated wall-to-lumen ratio. Capillary density in 1KG was reduced in the innervated and denervated states compared with controls. At 8-10 wk in the 1KG , arteriolar vasoconstriction was no longer significantly elevated. However, the vasodilated arteriolar diameter was smaller, wall-to-lumen ratio had increased further, and rarefaction of arterioles and capillaries was present. Thus, with time, structural mechanisms for increasing vascular resistance were seen to displace the active mechanism of vasoconstriction.