Immediate neural impact and incomplete compensation after semantic hub disconnection.
Immediate neural impact and incomplete compensation after semantic hub disconnection.
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DOI：
10.1038/s41467-023-42088-7
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发表时间：
2023-10-07
影响因子：
16.6
通讯作者：
Petkov, Christopher I
中科院分区：
文献类型：
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作者：
Kocsis, Zsuzsanna;Jenison, Rick L;Taylor, Peter N;Calmus, Ryan M;McMurray, Bob;Rhone, Ariane E;Sarrett, McCall E;Deifelt Streese, Carolina;Kikuchi, Yukiko;Gander, Phillip E;Berger, Joel I;Kovach, Christopher K;Choi, Inyong;Greenlee, Jeremy D;Kawasaki, Hiroto;Cope, Thomas E;Griffiths, Timothy D;Howard, Matthew A 3rd;Petkov, Christopher I
人类大脑通过广泛的神经系统来获取语义知识。广泛分布的系统是否依赖或能够在失去高度互联的枢纽后进行补偿是有争议的。我们报告了两名患者在语音预测任务期间的颅内记录，这些记录是在需要断开左前颞叶（ATL）（候选语义知识中心）的神经外科治疗前后几分钟获得的。在现代失联和预测编码框架的指导下，我们测试了各种假设，从单纯的神经网络中断到间接受影响的语言相关和语音处理站点的完全补偿。在ATL断开连接后，我们立即观察到记录的额叶和听觉部位的神经生理变化，为ATL作为语义中枢的重要性提供了直接证据。我们还获得了快速（尽管不完整）尝试神经网络补偿的证据，其中神经影响主要以预测编码框架规定的形式进行，具体而言，更普遍的是现代分离框架。总体结果验证了这些框架，并揭示了人类大脑在失去脑中枢后的直接影响和调整能力。人类的大脑是一个由高度互联的中枢组成的分布式系统。在这里，接受罕见手术的患者揭示了当一个关键中枢被移除时发生的即时影响和代偿性脑网络变化。
The human brain extracts meaning using an extensive neural system for semantic knowledge. Whether broadly distributed systems depend on or can compensate after losing a highly interconnected hub is controversial. We report intracranial recordings from two patients during a speech prediction task, obtained minutes before and after neurosurgical treatment requiring disconnection of the left anterior temporal lobe (ATL), a candidate semantic knowledge hub. Informed by modern diaschisis and predictive coding frameworks, we tested hypotheses ranging from solely neural network disruption to complete compensation by the indirectly affected language-related and speech-processing sites. Immediately after ATL disconnection, we observed neurophysiological alterations in the recorded frontal and auditory sites, providing direct evidence for the importance of the ATL as a semantic hub. We also obtained evidence for rapid, albeit incomplete, attempts at neural network compensation, with neural impact largely in the forms stipulated by the predictive coding framework, in specificity, and the modern diaschisis framework, more generally. The overall results validate these frameworks and reveal an immediate impact and capability of the human brain to adjust after losing a brain hub. The human brain is a distributed system composed of highly interconnected hubs. Here, patients undergoing a rare operation reveal the immediate impact and compensatory brain network changes that occur when a key hub is removed.