Activin selectively abolishes hippocampal long-term potentiation induced by weak tetanic stimulation in vivo
Activin selectively abolishes hippocampal long-term potentiation induced by weak tetanic stimulation in vivo
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DOI：
10.1254/jjp.75.87
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发表时间：
1997-09-01
期刊：
影响因子：
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通讯作者：
Nishiyama, N
中科院分区：
文献类型：
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作者：
Ikegaya, Y;Saito, H;Nishiyama, N
虽然神经营养因子或生长因子对海马突触可塑性的调节近年来已成为一个广泛研究的课题，但尚未有报道认为转化生长因子(TGF)- β超家族对此有贡献。在本研究中，我们研究了激活素（激活素是tgf - β超家族的一员）对麻醉大鼠齿状回长期增强（LTP）的影响。激活素对强直刺激（60 Hz， 0.27秒）诱导的LTP形成有显著的抑制作用，而对强强直刺激（60 Hz， 0.5秒）诱导的LTP形成无显著影响。这些结果表明，激活素选择性地阻断了阈值破伤风刺激引起的LTP的诱导。
Although modulation of hippocampal synaptic plasticity by neurotrophins or growth factors has recently become an extensively investigated subject, there are no reports arguing for the contribution of the transforming growth factor (TGF)-beta superfamily. In the present study, we examined the effect of activin, a member of the TGF-beta superfamily, on long-term potentiation (LTP) of the dentate gyrus in anesthetized rats. Activin significantly impaired the formation of LTP induced by tetanic stimulation (60 Hz for 0.27 sec), but not that by strong tetanic stimulation (60 Hz for 0.5 sec). These results suggest that activin selectively blocks the induction of LTP evoked by threshold tetanic stimulation.