ACUTE EFFECTS OF THE ORGANOPHOSPHATE PARAOXON ON SCHEDULE-CONTROLLED BEHAVIOR AND ESTERASE-ACTIVITY IN RATS - DOSE-RESPONSE RELATIONSHIPS
ACUTE EFFECTS OF THE ORGANOPHOSPHATE PARAOXON ON SCHEDULE-CONTROLLED BEHAVIOR AND ESTERASE-ACTIVITY IN RATS - DOSE-RESPONSE RELATIONSHIPS
复制标题
DOI：
10.1016/0091-3057(91)90108-e
复制
发表时间：
1991-12-01
影响因子：
3.6
通讯作者：
CHAMBERS, JE
中科院分区：
文献类型：
--
作者：
CARR, RL;CHAMBERS, JE
本文研究了急性腹腔注射对氧磷对雄性大鼠行为和生化指标的影响。 训练大鼠在FR 10强化时间表下按压杠杆。 大鼠注射3个亚致死剂量的对氧磷（0.5，0.75，和1.0毫克/公斤）和性能进行了监测，暴露后4天。 0.75和1.0 mg/kg剂量组第1天和第2天的反应率显著降低，但0.5 mg/kg剂量组无此现象，尽管所有剂量组均对脑和血浆胆碱酯酶产生抑制作用。 在脑AChE恢复之前，性能恢复。 有没有明确的阈值，脑乙酰胆碱酯酶抑制需要产生性能缺陷，也没有直接相关的显着抑制外周酶，可作为标记物（血浆aliesterases，丁酰胆碱酯酶，非iso-OMPA敏感的胆碱酯酶，和肝aliesterases）和性能缺陷，这表明其他非胆碱能靶点可能发挥作用，OP诱导的行为缺陷。
The effects of acute intraperitoneal administration of paraoxon on behavioral and biochemical parameters were studied in male rats. Rats were trained to press a lever under an FR10 schedule of reinforcement. Rats were injected with 3 sublethal doses of paraoxon (0.5, 0.75, and 1.0 mg/kg) and performance was monitored for four days after exposure. Response rates were depressed significantly for days 1 and 2 with 0.75 and 1.0 mg/kg, but not 0.5 mg/kg, even though there was inhibition of brain and plasma cholinesterases at all doses. Performance recovered prior to brain AChE recovery. There was no clear-cut threshold of brain AChE inhibition required to yield performance deficits, nor was there a direct correlation between significant inhibition in peripheral enzymes which could serve as markers (plasma aliesterases, butyrylcholinesterase, non-iso-OMPA-sensitive cholinesterase, and hepatic aliesterases) and performance deficits, suggesting that other noncholinergic targets may play a role in OP-induced behavioral deficits.