High fat diet intake during pre and periadolescence impairs learning of a conditioned place preference in adulthood.
High fat diet intake during pre and periadolescence impairs learning of a conditioned place preference in adulthood.
复制标题
DOI：
10.1186/1744-9081-7-21
复制
发表时间：
2011-06-26
期刊：
影响因子：
--
通讯作者：
Sotak KL
中科院分区：
文献类型：
--
作者：
Privitera GJ;Zavala AR;Sanabria F;Sotak KL
调节条件性位置偏好（CPP）学习的脑区在青春期前和青春期前后经历了显著的发展。在此发育期和成年期食用高脂肪（HF）饮食可导致啮齿动物的学习障碍。目前的研究测试是否HF饮食摄入量，消费只有在前和青春期，将足以导致损害使用CPP程序。在出生后第21-40天（PD），将大鼠随机分配食用HF或低脂肪（LF）饮食，然后放回标准实验室食物饮食。使用HF Cheetos®作为非条件刺激（US）的20天CPP程序在第二天（PD 41）或40天后（PD 81）开始。另一组成年大鼠从PD 61开始接受为期20天的HF饮食，然后从PD 81开始立即接受为期20天的CPP程序。青少年前和青少年期暴露于LF饮食或成人暴露于HF饮食不会干扰HF食物诱导的CPP的发展，因为这些群体对HF Cheetos®食物配对隔室表现出强烈的偏好。然而，青春期前和青春期前后暴露于HF饮食会损害HF食物诱导的CPP的发展，无论是在暴露于HF饮食后立即评估还是在暴露于HF饮食后40天评估，并且尽管显示HF Cheetos®的消耗量增加。仅在青春期前和青春期前后摄入HF饮食，对学习有长期影响，并持续到成年。
Brain regions that mediate learning of a conditioned place preference (CPP) undergo significant development in pre and periadolescence. Consuming a high fat (HF) diet during this developmental period and into adulthood can lead to learning impairments in rodents. The present study tested whether HF diet intake, consumed only in pre and periadolescence, would be sufficient to cause impairments using a CPP procedure. Rats were randomly assigned to consume a HF or a low fat (LF) diet during postnatal days (PD) 21-40 and were then placed back on a standard lab chow diet. A 20-day CPP procedure, using HF Cheetos® as the unconditioned stimulus (US), began either the next day (PD 41) or 40 days later (PD 81). A separate group of adult rats were given the HF diet for 20 days beginning on PD 61, and then immediately underwent the 20-day CPP procedure beginning on PD 81. Pre and periadolescent exposure to a LF diet or adult exposure to a HF diet did not interfere with the development of a HF food-induced CPP, as these groups exhibited robust preferences for the HF Cheetos® food-paired compartment. However, pre and periadolescent exposure to the HF diet impaired the development of a HF food-induced CPP regardless of whether it was assessed immediately or 40 days after the exposure to the HF diet, and despite showing increased consumption of the HF Cheetos® in conditioning. Intake of a HF diet, consumed only in pre and periadolescence, has long-lasting effects on learning that persist into adulthood.
登录
查看更多内容
影响因子：
3.8
作者：
Lassiter, T. Leon;Ryde, Ian T.;Slotkin, Theodore A.
通讯作者：
Slotkin, Theodore A.
影响因子：
2.9
作者：
AKBARI, HM;KRAMER, HK;AZMITIA, EC
通讯作者：
AZMITIA, EC
影响因子：
4.9
作者：
Hollopeter, G;Erickson, JC;Palmiter, RD
通讯作者：
Palmiter, RD
影响因子：
5.3
作者：
Floresco, SB;Blaha, CD;Phillips, AG
通讯作者：
Phillips, AG
影响因子：
6.9
作者：
Hwang, Ling-Ling;Wang, Chien-Hua;Chiou, Lih-Chu
通讯作者：
Chiou, Lih-Chu