Bone, inflammation, and inflammatory bowel disease.
Bone, inflammation, and inflammatory bowel disease.
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DOI：
10.1007/s11914-011-0077-9
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发表时间：
2011-12-01
影响因子：
4.3
通讯作者：
Zaidi, Mone
中科院分区：
文献类型：
--
作者：
Agrawal, Manasi;Arora, Shitij;Zaidi, Mone
骨质疏松症是炎症性肠病（IBD）患者发病的主要原因。骨丢失是一个早期的全身性过程，甚至在临床疾病表现之前就发生了。骨疾病可归因于维生素D缺乏、类固醇使用和/或全身炎症。在这篇综述中，我们讨论了炎症细胞因子和其他介质介导的骨丢失的分子途径。进一步的研究将有望阐明炎症诱导骨丢失的机制，并指导有效的治疗方法。
Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.