A COMPARATIVE STUDY OF SCHISTOSOMA MANSONI INFECTIONS IN MICE, GERBILS, MULTIMAMMATE RATS AND HAMSTERS. II. QUALITATIVE PATHOLOGICAL DIFFERENCES.
A COMPARATIVE STUDY OF SCHISTOSOMA MANSONI INFECTIONS IN MICE, GERBILS, MULTIMAMMATE RATS AND HAMSTERS. II. QUALITATIVE PATHOLOGICAL DIFFERENCES.
复制标题
小鼠、沙鼠、多乳鼠和仓鼠曼氏血吸虫感染的比较研究。
DOI：
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发表时间：
1965
影响因子：
3.3
通讯作者：
A. Cheever
中科院分区：
文献类型：
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作者：
A. Cheever
总结
在小鼠、多乳鼠、仓鼠和沙鼠中观察到宿主对曼氏血吸虫感染的反应有质的差异。
肉芽肿内的中央坏死和肝实质坏死在小鼠中最常见。 Hoeppli 现象经常在多乳鼠的卵中观察到，但在其他物种中并未观察到。仓鼠肝脏中的肉芽肿具有典型的组织细胞性，而沙鼠肝脏中的肉芽肿通常含有大量肥大细胞。
周围肝淋巴管的极度扩张在多乳鼠中很常见，但在其他物种中并不常见。
淀粉样变性是仓鼠长期感染的常见并发症。该物种的周围水肿、腹水和胸腔积液继发于肾淀粉样变性。
仅在小鼠中观察到明显的胆管增生。在许多长期感染的小鼠中，这些导管周围存在纤维化。
门静脉纤维化和门静脉炎在小鼠中比在其他物种中更为明显，并且在 C3H 小鼠中最为明显。门静脉纤维化与人肝血吸虫病的管干纤维化有轻微相似之处。
在长期感染的小鼠中偶尔会看到蠕虫死亡的直接或间接证据，但在其他物种中没有发现。
Summary
Qualitative differences in host response to Schistosoma mansoni infection were observed in mice, multimammate rats, hamsters and gerbils.
Central necrosis within granulomas and hepatic parenchymal necrosis were most frequent in mice. The Hoeppli phenomenon was frequently observed about eggs in the multimammate rat but was not seen in other species. Granulomas in the hamster liver were characteristically histiocytic while those in the gerbil liver often contained numerous mast cells.
Extreme dilatation of peripheral hepatic lymphatics was frequent in multimammate rats but uncommon in other species.
Amyloidosis was a frequent complication of prolonged infection in hamsters. Peripheral edema, ascites and pleural effusions in this species were secondary to renal amyloidosis.
Marked hyperplasia of bile ducts was observed only in mice. Fibrosis about these ducts was present in many mice with prolonged infections.
Portal fibrosis and pylephlebitis were more marked in mice than in other species and were most marked in C3H mice. The resemblance of portal fibrosis to the pipestem fibrosis of human hepatic schistosomiasis was slight.
Direct or indirect evidence of worm death was seen occasionally in mice with prolonged infections but was not noted in other species.